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Bcl-B peptide

Scan QR to view Datasheet Catalog #    MBS843939 Bcl-B peptide
Unit / Price
0.05 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Bcl-B, Peptide

 Also Known As   

Bcl-B Blocking Peptide

 Product Gene Name   

Bcl-B peptide

[Similar Products]
 Antibody/Peptide Pairs    Bcl-B peptide (MBS843939) is used for blocking the activity of Bcl-B antibody (MBS840647)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606910
 3D Structure    ModBase 3D Structure for Q9HD36
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 Form/Format    50 ug (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 1% BSA and 0.02% thimerosal.
Appearance: Colorless liquid
 Concentration    0.5 mg/ml (lot specific)
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 Handling    The peptide solution should be gently mixed before use.
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 Preparation and Storage    At -20 degree C
Shelf Life: 12 months
 Other Notes    Small volumes of Bcl-B peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for Bcl-B peptide   

Western Blot (WB)

 Application Notes for Bcl-B peptide    The peptide is used for blocking the antibody activity of Bcl-B. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37 degree C.
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NCBI/Uniprot data below describe general gene information for Bcl-B. It may not necessarily be applicable to this product.
 NCBI GI #    807201162
 NCBI GeneID    10017
 NCBI Accession #    NP_001293097.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001306168.1 [Other Products]
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 UniProt Primary Accession #    Q9HD36 [Other Products]
 UniProt Secondary Accession #    Q3SX80; Q52LQ9; Q8TCS9 [Other Products]
 UniProt Related Accession #    Q9HD36 [Other Products]
 Molecular Weight    21,973 Da
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 NCBI Official Full Name    bcl-2-like protein 10 isoform 1
 NCBI Official Synonym Full Names    BCL2-like 10 (apoptosis facilitator)
 NCBI Official Symbol    BCL2L10 [Similar Products]
 NCBI Official Synonym Symbols   
Boo; Diva; BCL-B; bcl2-L-10
[Similar Products]
 NCBI Protein Information    bcl-2-like protein 10
 UniProt Protein Name    Bcl-2-like protein 10
 UniProt Synonym Protein Names   
Anti-apoptotic protein NrH; Apoptosis regulator Bcl-B
 UniProt Gene Name    BCL2L10 [Similar Products]
 UniProt Synonym Gene Names    BCLB; Bcl2-L-10 [Similar Products]
 UniProt Entry Name    B2L10_HUMAN
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 NCBI Summary for Bcl-B    The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Bcl-B    BCL2L10: Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1. Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. Belongs to the Bcl-2 family.

Protein type: Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q21

Cellular Component: mitochondrial outer membrane; nuclear membrane; mitochondrion; membrane; integral to membrane; cytosol

Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity

Biological Process: caspase activation; DNA damage response, signal transduction resulting in induction of apoptosis; female gamete generation; spermatogenesis; negative regulation of apoptosis
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 Research Articles on Bcl-B    1. polyubiquitination and proteasomal turnover dictate the expression level and anti-apoptotic capacity of Bcl-B
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Bcl-B peptideDiseases associated with Bcl-B peptide
 Reference Product  PubMed Publications
 BAX peptide  >5 publications with Bcl-B and BAX
 BCL2L2 peptide  >3 publications with Bcl-B and BCL2L2
 BCL2L1 peptide  >3 publications with Bcl-B and BCL2L1
 BAK1 peptide  >2 publications with Bcl-B and BAK1
 Disease Name  Pubmed Publications
 Infertility, Female Antibodies  >2 publications with Bcl-B and Infertility, Female
 Breast Neoplasms Antibodies  >2 publications with Bcl-B and Breast Neoplasms
 Necrosis Antibodies  >2 publications with Bcl-B and Necrosis
 Fetal Death Antibodies  >1 publications with Bcl-B and Fetal Death
 Infertility, Male Antibodies  >1 publications with Bcl-B and Infertility, Male
 Lung Diseases Antibodies  >1 publications with Bcl-B and Lung Diseases
 Inflammation Antibodies  >1 publications with Bcl-B and Inflammation
Organs/Tissues associated with Bcl-B peptide
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with Bcl-B and Kidney
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