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raf1a peptide :: C-Raf (C-terminus) Peptide

Scan QR to view Datasheet Catalog #    MBS474008
Testing Data
Unit / Price
0.05 mg  /  $130 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C-Raf (C-terminus) Peptide (raf1a), Peptide

 Also Known As   

C-Raf (C-terminus) Peptide

 Product Gene Name   

raf1a peptide

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Peptide Sequence: C-Raf (C-terminu s) synthetic peptide correspond ing to amino acids 637 to 648 in human C-Raf. This sequence is conserved in C-Rafs from many species, and is not found in A-Raf or B-Raf.
 Chromosome Location    Chromosome: 23; NC_007134.5 (4764341..4775456)
 3D Structure    ModBase 3D Structure for Q90458
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 Specificity    The peptide is specifically recognized by anti-C-Raf (Cterminus) antibody (RP2071) in ELISA, and has been shown to block the reactivity of RP2071 during Western blot. In addition, the peptide is recommended for use in blocking RP2071 reactivity in immunocytochemistry.
 Form/Format    Blocking Peptide is supplied in 50ul phosphate-buffered saline and 0.05% sodium azide.
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 Preparation and Storage    Store at -20 degree C. Stable for 1 year.
 Other Notes    Small volumes of raf1a peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for raf1a peptide

   The Ras-Raf-MAP kinase signaling pathway is involved in control of cell proliferation and differentiation. The Raf kinase family includes A-Raf, BRaf, and C-Raf. Each family member has three highly conserved regions (CR1-3). The N-terminal CR1 contains the Ras-GTP-binding domain. The CR2 contains a negative regulatory serine residue (C-Raf (S259)/B-Raf (S365)) that may bind 14-3-3 proteins. The CR3 is the catalytic domain that contains phosphorylation sites for Raf-regulating enzymes within two segments, the N-region and the activation segment. Activation of C-Raf involves phosphorylation at many sites including Ser-338, Tyr-341, and multiple catalytic domain sites. EGF receptor activation leads to phosphorylation of Ser-471, which is critical for C-Raf kinase activity and is required for interaction with MEK. In B-Raf, the corresponding conserved site is Ser-578, and mutation of this residue to alanine produces an inactivate kinase. Thus, this Raf phosphorylation site may be critical for kinase activity and may be important for MEK binding and activation.
 Application Notes for raf1a peptide    Blocking: 1:1,000
ELISA: 50 ng/well
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 Testing Data of raf1a peptide    raf1a peptide Testing Data image
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NCBI/Uniprot data below describe general gene information for raf1a. It may not necessarily be applicable to this product.
 NCBI GI #    534977
 NCBI GeneID    30716
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 UniProt Primary Accession #    Q90458 [Other Products]
 UniProt Related Accession #    Q6BE22; Q76FQ3; Q76I87; Q7ZTR8; Q7ZZW3; Q90458 [Other Products]
 Molecular Weight    34,871 Da [Similar Products]
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 NCBI Official Full Name    c-raf
 NCBI Official Synonym Full Names    v-raf-1 murine leukemia viral oncogene homolog 1a
 NCBI Official Symbol    raf1a [Similar Products]
 NCBI Official Synonym Symbols   
craf; raf1; c-raf
[Similar Products]
 NCBI Protein Information    RAF proto-oncogene serine/threonine-protein kinase; serine/threonine protein kinase RAF1; murine leukemia viral oncogene homolog; v-raf-1 murine leukemia viral oncogene homolog 1
 UniProt Protein Name    C-raf protein
 UniProt Gene Name    raf1a [Similar Products]
 UniProt Synonym Gene Names    c-raf [Similar Products]
 UniProt Entry Name    Q90458_DANRE
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Product References and Citations for raf1a peptide

   • Mason, C.S. et al. (1999) EMBOJ 18(8):2137.
• Zhu, J. et al. (2005). Mol. Biol. Cell 16:4733.
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 Research Articles on raf1a    1. analysis of the roles of Raf- and PI3K-signalling pathways in melanoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with raf1a peptide
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Down-stream Signal Transduction Pathway antibodies  Down-stream Signal Transduction Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram
 ERK1 - ERK2 MAPK Cascade Pathway antibodies  ERK1 - ERK2 MAPK Cascade Pathway Diagram
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