NP_000558.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
C-reactive protein
NCBI Official Synonym Full Names
C-reactive protein, pentraxin-related
NCBI Official Synonym Symbols
NCBI Protein Information
C-reactive protein
UniProt Protein Name
C-reactive protein
UniProt Synonym Gene Names
UniProt Entry Name
CRP_HUMAN
NCBI Summary for CRP
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
UniProt Comments for CRP
CRP: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Belongs to the pentaxin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q23.2
Cellular Component: extracellular region; extracellular space
Molecular Function: calcium ion binding; choline binding; complement component C1q binding; low-density lipoprotein binding; low-density lipoprotein receptor binding; protein binding; virion binding
Biological Process: acute-phase response; defense response to Gram-positive bacterium; inflammatory response; negative regulation of vasodilation; opsonization; positive regulation of superoxide release
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Products associated with CRP peptide
Pathways associated with CRP peptide
Diseases associated with CRP peptide
Organs/Tissues associated with CRP peptide
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