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C14orf169 peptide

Scan QR to view Datasheet Catalog #    MBS659528 C14orf169 peptide
Unit / Price
0.1 mg  /  $400 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C14orf169, Peptide

 Also Known As   

C14orf169 (NO66, C14orf169, chromosome 14 open reading frame 169, FLJ21802, NO66, MAPJD) (Control Peptide)

 Product Gene Name   

C14orf169 peptide

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 14; NC_000014.8 (73957644..73960105). Location: 14q24.3
 OMIM    611919
 3D Structure    ModBase 3D Structure for Q9H6W3
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 Purity/Purification    Highly Purified
Highly Purified
 Form/Format    Supplied as a lyophilized powder in PBS.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of C14orf169 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for C14orf169 peptide

   C-terminus of aa-GAQHSDSKDPR.
 Product Categories/Family for C14orf169 peptide    Molecular Biology; MB-Transcription Factors
 Applications Tested/Suitable for C14orf169 peptide   

ELISA (EL/EIA)

 Application Notes for C14orf169 peptide    Suitable for use in ELISA.
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NCBI/Uniprot data below describe general gene information for C14orf169. It may not necessarily be applicable to this product.
 NCBI GI #    48735363
 NCBI GeneID    79697
 NCBI Accession #    AAH71954.1 [Other Products]
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 UniProt Primary Accession #    Q9H6W3 [Other Products]
 UniProt Secondary Accession #    B4DT02 [Other Products]
 UniProt Related Accession #    Q9H6W3 [Other Products]
 Molecular Weight    71,086 Da [Similar Products]
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 NCBI Official Full Name    Chromosome 14 open reading frame 169
 NCBI Official Synonym Full Names    chromosome 14 open reading frame 169
 NCBI Official Symbol    C14orf169 [Similar Products]
 NCBI Official Synonym Symbols   
ROX; NO66; MAPJD
[Similar Products]
 NCBI Protein Information    bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; hsNO66; nucleolar protein 66; ribosomal oxygenase NO66; histone lysine demethylase NO66; lysine-specific demethylase NO66; MYC-associated protein with JmjC domain; 60S ribosomal protein L8 histidine hydroxylase
 UniProt Protein Name    Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
 UniProt Synonym Protein Names   
60S ribosomal protein L8 histidine hydroxylase; Histone lysine demethylase NO66; Myc-associated protein with JmjC domain; Nucleolar protein 66; hsNO66; Ribosomal oxygenase NO66
 UniProt Gene Name    NO66 [Similar Products]
 UniProt Synonym Gene Names    C14orf169; MAPJD; hsNO66; ROX [Similar Products]
 UniProt Entry Name    NO66_HUMAN
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 UniProt Comments for C14orf169    Function: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation

By similarity. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. Ref.1 Ref.5 Ref.9

Catalytic activity: Protein N6,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2 = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2. Ref.9Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2 = protein L-lysine + succinate + formaldehyde + CO2. Ref.9L-histidine-[60S ribosomal protein L8] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L8] + succinate + CO2. Ref.9

Cofactor: Binds 1 Fe2+ ion per subunit

By similarity.

Subunit structure: Interacts with SP7/OSX; the interaction is direct

By similarity. Interacts with MYC. Interacts with PHF19; leading to its recruitment to H3K36me3 sites. Ref.5 Ref.8

Subcellular location: Nucleus › nucleolus. Nucleus › nucleoplasm. Note: Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli. Ref.1 Ref.5

Tissue specificity: Widely expressed. Overexpressed in lung carcinomas. Ref.1 Ref.5

Sequence similarities: Belongs to the MINA53/NO66 family. NO66 subfamily.Contains 1 JmjC domain.
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 Research Articles on C14orf169    1. hinge domain-dependent oligomerization of NO66 is essential for inhibition of Osx-dependent gene activation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with C14orf169 peptideOrgans/Tissues associated with C14orf169 peptide
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with C14orf169 and Inflammation
 Necrosis Antibodies  >1 publications with C14orf169 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2 publications with C14orf169 and Bone
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