NP_055512.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,569 Da
NCBI Official Full Name
carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform 1
NCBI Official Synonym Full Names
nitric oxide synthase 1 adaptor protein
NCBI Protein Information
carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
UniProt Protein Name
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
UniProt Synonym Protein Names
C-terminal PDZ ligand of neuronal nitric oxide synthase protein; Nitric oxide synthase 1 adaptor protein
UniProt Synonym Gene Names
UniProt Entry Name
CAPON_HUMAN
NCBI Summary for NOS1AP
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]
UniProt Comments for NOS1AP
NOS1AP: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: caveola; cytosol; mitochondrion; nuclear membrane; nucleus; perinuclear region of cytoplasm; sarcolemma; sarcoplasmic reticulum membrane; T-tubule; Z disc
Molecular Function: nitric-oxide synthase binding; protein binding
Biological Process: chemical signal regulation of heart rate; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; regulation of apoptosis; regulation of nitric oxide biosynthetic process; regulation of nitric-oxide synthase activity
Disease: Qt Interval, Variation In
Research Articles on NOS1AP
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Products associated with NOS1AP blocking peptide
Pathways associated with NOS1AP blocking peptide
Diseases associated with NOS1AP blocking peptide
Organs/Tissues associated with NOS1AP blocking peptide
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