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CD274 peptide :: CD274 / PD-L1 Peptide

Scan QR to view Datasheet Catalog #    MBS425798 CD274 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD274 / PD-L1, Peptide

 Also Known As   

CD274 / PD-L1 Immunizing Peptide

 Product Synonym Names    CD274; CD274 antigen; PD-L1; PDCD1LG1; B7-H; B7H1; PDL1; PDCD1L1; programmed cell death 1 ligand 1; PDL1; HGNC: 17635; CD274 molecule; MGC142294; MGC142296; CD274 / PD-L1
 Product Gene Name   

CD274 peptide

[Similar Products]
 Product Synonym Gene Name    PD-L1 [Similar Products]
 Antibody/Peptide Pairs    CD274 / PD-L1 peptide (MBS425798) is used for blocking the activity of CD274/PD-L1 antibody (MBS421103)
 Antibody/Peptide Pairs    CD274 / PD-L1 peptide (MBS425798) is used for blocking the activity of CD274/PD-L1 antibody (MBS423706)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    CKKQSDTHLE ET
 OMIM    605402
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 Species Reactivity    Human
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of CD274 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for CD274. It may not necessarily be applicable to this product.
 NCBI GI #    7661534
 NCBI GeneID    29126
 NCBI Accession #    NP_054862.1 [Other Products]
 NCBI Related Accession #    NP_001254635.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_014143.3 [Other Products]
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 UniProt Secondary Accession #    Q14CJ2; Q2V8D5; Q66RK1; Q6WEX4; Q9NUZ5; B2RBA2; B4DU27 [Other Products]
 UniProt Related Accession #    Q9NZQ7 [Other Products]
 Molecular Weight    20,454 Da
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 NCBI Official Full Name    programmed cell death 1 ligand 1 isoform a
 NCBI Official Synonym Full Names    CD274 molecule
 NCBI Official Symbol    CD274 [Similar Products]
 NCBI Official Synonym Symbols   
B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1
[Similar Products]
 NCBI Protein Information    programmed cell death 1 ligand 1
 UniProt Protein Name    Programmed cell death 1 ligand 1
 UniProt Synonym Protein Names   
B7 homolog 1; B7-H1; CD_antigen: CD274
 Protein Family    Programmed cell death
 UniProt Gene Name    CD274 [Similar Products]
 UniProt Synonym Gene Names    B7H1; PDCD1L1; PDCD1LG1; PDL1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7-H1 [Similar Products]
 UniProt Entry Name    PD1L1_HUMAN
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 NCBI Summary for CD274    This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
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 UniProt Comments for CD274    CD274: Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p24

Cellular Component: endomembrane system; external side of plasma membrane; integral to membrane; plasma membrane

Molecular Function: protein binding

Biological Process: cell surface receptor linked signal transduction; immune response; negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; positive regulation of cell migration; positive regulation of T cell proliferation; regulation of activated T cell proliferation; response to cytokine stimulus; signal transduction; T cell costimulation
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 Research Articles on CD274    1. High expression of B7H1 is associated with Colorectal Cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD274 peptidePathways associated with CD274 peptide
 Reference Product  PubMed Publications
 PDCD1 peptide  >520 publications with CD274 and PDCD1
 CD80 peptide  >414 publications with CD274 and CD80
 PDCD1LG2 peptide  >204 publications with CD274 and PDCD1LG2
 HLA-DRB1 peptide  >1 publications with CD274 and HLA-DRB1
 LCK peptide  >1 publications with CD274 and LCK
 PTPN11 peptide  >1 publications with CD274 and PTPN11
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 PD-1 Signaling Pathway antibodies  PD-1 Signaling Pathway Diagram
Diseases associated with CD274 peptideOrgans/Tissues associated with CD274 peptide
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >160 publications with CD274 and Disease Models, Animal
 Inflammation Antibodies  >153 publications with CD274 and Inflammation
 Lung Neoplasms Antibodies  >123 publications with CD274 and Lung Neoplasms
 Lung Diseases Antibodies  >114 publications with CD274 and Lung Diseases
 Adenocarcinoma Antibodies  >104 publications with CD274 and Adenocarcinoma
 Liver Diseases Antibodies  >102 publications with CD274 and Liver Diseases
 Neoplasms, Experimental Antibodies  >92 publications with CD274 and Neoplasms, Experimental
 Necrosis Antibodies  >92 publications with CD274 and Necrosis
 Nervous System Diseases Antibodies  >89 publications with CD274 and Nervous System Diseases
 Kidney Diseases Antibodies  >69 publications with CD274 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >997 publications with CD274 and Blood
 Lung Antibodies  >168 publications with CD274 and Lung
 Lymph Node Antibodies  >94 publications with CD274 and Lymph Node
 Bone Antibodies  >89 publications with CD274 and Bone
 Skin Antibodies  >68 publications with CD274 and Skin
 Brain Antibodies  >46 publications with CD274 and Brain
 Pancreas Antibodies  >31 publications with CD274 and Pancreas
 Stomach Antibodies  >22 publications with CD274 and Stomach
 Placenta Antibodies  >20 publications with CD274 and Placenta
 Prostate Antibodies  >11 publications with CD274 and Prostate
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