NP_001030086.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
calsenilin isoform 2
NCBI Official Synonym Full Names
Kv channel interacting protein 3, calsenilin
NCBI Protein Information
calsenilin
UniProt Protein Name
Calsenilin
UniProt Synonym Protein Names
A-type potassium channel modulatory protein 3; DRE-antagonist modulator; DREAM; Kv channel-interacting protein 3; KChIP3
UniProt Synonym Gene Names
UniProt Entry Name
CSEN_HUMAN
NCBI Summary for KCNIP3
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNIP3
calsenilin: a small calcium-binding protein. Member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Modulates K4 voltage-gated potassium channels. May regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Also functions as a calcium-regulated transcriptional repressor, and to interact with presenilins. May play a role in the regulation of PSEN2 proteolytic processing.
Protein type: Transcription factor; Calcium-binding
Chromosomal Location of Human Ortholog: 2q21.1
Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; endoplasmic reticulum; dendrite; nerve terminal; cytosol; nucleus
Molecular Function: protein C-terminus binding; potassium channel regulator activity; potassium channel activity; DNA binding; sequence-specific DNA binding; voltage-gated ion channel activity; calcium ion binding; calcium-dependent protein binding; transcription corepressor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; intracellular protein transport; behavioral response to pain; transcription, DNA-dependent; apoptosis; regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; signal transduction; sensory perception of pain
Research Articles on KCNIP3
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Products associated with KCNIP3 peptide
Pathways associated with KCNIP3 peptide
Diseases associated with KCNIP3 peptide
Organs/Tissues associated with KCNIP3 peptide
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