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PPIA peptide :: Cyclophilin A / PPIA Peptide

Scan QR to view Datasheet Catalog #    MBS426780 PPIA peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cyclophilin A / PPIA, Peptide

 Also Known As   

Cyclophilin A / PPIA Immunizing Peptide

 Product Synonym Names    PPIA; peptidylprolyl isomerase A (cyclophilin A); HGNC: 9253; CYPA; CYPH; MGC12404; T cell cyclophilin; cyclosporin A-binding protein; peptidyl-prolyl cis-trans isomerase A; peptidylprolyl isomerase A; rotamase; MGC117158; MGC23397; PPIase A; Cyclophilin A; Cyclophilin A / PPIA
 Product Gene Name   

PPIA peptide

[Similar Products]
 Antibody/Peptide Pairs    Cyclophilin A / PPIA peptide (MBS426780) is used for blocking the activity of Cyclophilin A/PPIA antibody (MBS420056)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-ERFGSRNG KTSKK
 OMIM    123840
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 Species Reactivity    Human, Mouse, Rat, Dog, Pig, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of PPIA peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for PPIA. It may not necessarily be applicable to this product.
 NCBI GI #    10863927
 NCBI GeneID    5478
 NCBI Accession #    NP_066953.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021130.4 [Other Products]
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 UniProt Secondary Accession #    P05092; Q3KQW3; Q567Q0; Q6IBU5; Q96IX3; Q9BRU4; Q9BTY9; Q9UC61; A8K220 [Other Products]
 UniProt Related Accession #    P62937 [Other Products]
 Molecular Weight    11,418 Da
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 NCBI Official Full Name    peptidyl-prolyl cis-trans isomerase A isoform 1
 NCBI Official Synonym Full Names    peptidylprolyl isomerase A
 NCBI Official Symbol    PPIA [Similar Products]
 NCBI Official Synonym Symbols   
CYPA; CYPH; HEL-S-69p
[Similar Products]
 NCBI Protein Information    peptidyl-prolyl cis-trans isomerase A
 UniProt Protein Name    Peptidyl-prolyl cis-trans isomerase A
 UniProt Synonym Protein Names   
Cyclophilin A; Cyclosporin A-binding protein; Rotamase A
 Protein Family    Peptidyl-prolyl cis-trans isomerase
 UniProt Gene Name    PPIA [Similar Products]
 UniProt Synonym Gene Names    CYPA; PPIase A [Similar Products]
 UniProt Entry Name    PPIA_HUMAN
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 NCBI Summary for PPIA    This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PPIA    PPIA: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Interacts with HIV-1 Capsid protein. Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase. Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.

Protein type: Isomerase; Cyclophilin; RNA-binding; EC 5.2.1.8

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: cytosol; extracellular region; extracellular space; focal adhesion; membrane; nucleus

Molecular Function: peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; unfolded protein binding; virion binding

Biological Process: entry into host cell; leukocyte migration; positive regulation of protein secretion; positive regulation of viral genome replication; protein folding; protein peptidyl-prolyl isomerization; regulation of viral genome replication; release of virus from host; RNA-dependent DNA replication; uncoating of virus; viral envelope fusion with host membrane; viral infectious cycle; virus assembly
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 Research Articles on PPIA    1. Extracellular CyPA activates platelets via cluster of differentiation 147-mediated phosphoinositid-3-kinase/Akt-signaling, leading to enhanced adhesion and thrombus formation independently of intracellular CyPA.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PPIA peptidePathways associated with PPIA peptide
 Reference Product  PubMed Publications
 UBC peptide  >23 publications with PPIA and UBC
 CFL1 peptide  >3 publications with PPIA and CFL1
 TAGLN2 peptide  >2 publications with PPIA and TAGLN2
 PFN1 peptide  >1 publications with PPIA and PFN1
 MAPK1 peptide  >1 publications with PPIA and MAPK1
 Products by Pathway  Pathway Diagram
 APOBEC3G Mediated Resistance To HIV-1 Infection Pathway antibodies  APOBEC3G Mediated Resistance To HIV-1 Infection Pathway Diagram
 Assembly Of The HIV Virion Pathway antibodies  Assembly Of The HIV Virion Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Binding And Entry Of HIV Virion Pathway antibodies  Binding And Entry Of HIV Virion Pathway Diagram
 Budding And Maturation Of HIV Virion Pathway antibodies  Budding And Maturation Of HIV Virion Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Early Phase Of HIV Life Cycle Pathway antibodies  Early Phase Of HIV Life Cycle Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
Diseases associated with PPIA peptideOrgans/Tissues associated with PPIA peptide
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >18 publications with PPIA and Inflammation
 Cardiovascular Diseases Antibodies  >18 publications with PPIA and Cardiovascular Diseases
 Necrosis Antibodies  >14 publications with PPIA and Necrosis
 Heart Diseases Antibodies  >14 publications with PPIA and Heart Diseases
 Neoplasms, Experimental Antibodies  >13 publications with PPIA and Neoplasms, Experimental
 Lung Diseases Antibodies  >9 publications with PPIA and Lung Diseases
 Nervous System Diseases Antibodies  >9 publications with PPIA and Nervous System Diseases
 Breast Neoplasms Antibodies  >8 publications with PPIA and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >7 publications with PPIA and Ovarian Neoplasms
 Brain Diseases Antibodies  >7 publications with PPIA and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >36 publications with PPIA and Blood
 Muscle Antibodies  >26 publications with PPIA and Muscle
 Brain Antibodies  >21 publications with PPIA and Brain
 Heart Antibodies  >17 publications with PPIA and Heart
 Liver Antibodies  >14 publications with PPIA and Liver
 Bone Antibodies  >14 publications with PPIA and Bone
 Lung Antibodies  >14 publications with PPIA and Lung
 Kidney Antibodies  >13 publications with PPIA and Kidney
 Vascular Antibodies  >11 publications with PPIA and Vascular
 Adipose Tissue Antibodies  >9 publications with PPIA and Adipose Tissue
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