AAG61157.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
83,469 Da
NCBI Official Full Name
DBC2
NCBI Official Synonym Full Names
Rho-related BTB domain containing 2
NCBI Official Synonym Symbols
NCBI Protein Information
rho-related BTB domain-containing protein 2; deleted in breast cancer 2 gene protein; p83
UniProt Protein Name
Rho-related BTB domain-containing protein 2
UniProt Synonym Protein Names
Deleted in breast cancer 2 gene protein; p83
UniProt Synonym Gene Names
UniProt Entry Name
RHBT2_HUMAN
NCBI Summary for DBC2
The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
UniProt Comments for DBC2
RHOBTB2: is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Protein type: G protein, monomeric; G protein; G protein, monomeric, Rho
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: plasma membrane; cytosol
Molecular Function: GTP binding
Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
Research Articles on DBC2
Precautions
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Pathways associated with DBC2 peptide
Diseases associated with DBC2 peptide
Organs/Tissues associated with DBC2 peptide
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