NP_009173.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,063 Da
NCBI Official Full Name
ATP-dependent RNA helicase DDX19B isoform 1
NCBI Official Synonym Full Names
DEAD-box helicase 19B
NCBI Protein Information
ATP-dependent RNA helicase DDX19B
UniProt Protein Name
ATP-dependent RNA helicase DDX19B
UniProt Synonym Protein Names
DEAD box RNA helicase DEAD5; DEAD box protein 19B
UniProt Synonym Gene Names
UniProt Entry Name
DD19B_HUMAN
NCBI Summary for DDX19B
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for DDX19B
DDX19B: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.4.13; Helicase; RNA-binding
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: cytoplasm; membrane; nuclear envelope; nuclear membrane; nuclear pore; nucleus
Molecular Function: ATP binding; ATP-dependent RNA helicase activity; helicase activity; protein binding; RNA binding
Biological Process: mRNA export from nucleus; protein transport; RNA secondary structure unwinding
Research Articles on DDX19B
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Diseases associated with DDX19B blocking peptide
Organs/Tissues associated with DDX19B blocking peptide
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