NP_065691.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,124 Da
NCBI Official Full Name
DCN1-like protein 1 isoform 1
NCBI Official Synonym Full Names
defective in cullin neddylation 1 domain containing 1
NCBI Official Synonym Symbols
RP42; SCRO; Tes3; DCNL1; SCCRO; DCUN1L1 [Similar Products]
NCBI Protein Information
DCN1-like protein 1
UniProt Protein Name
DCN1-like protein 1
UniProt Synonym Protein Names
DCUN1 domain-containing protein 1; Defective in cullin neddylation protein 1-like protein 1; Squamous cell carcinoma-related oncogene
UniProt Synonym Gene Names
UniProt Entry Name
DCNL1_HUMAN
UniProt Comments for DCUN1D1
DCUN1D1: Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression.
Protein type: Ubiquitin conjugating system; Oncoprotein
Chromosomal Location of Human Ortholog: 3q26.3
Cellular Component: nucleus; ubiquitin ligase complex
Molecular Function: protein binding; small conjugating protein binding; ubiquitin conjugating enzyme binding
Biological Process: positive regulation of ubiquitin-protein ligase activity; protein neddylation
Research Articles on DCUN1D1
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Diseases associated with DCUN1D1 blocking peptide
Organs/Tissues associated with DCUN1D1 blocking peptide
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