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DIO2 peptide

Scan QR to view Datasheet Catalog #    MBS425448 DIO2 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DIO2, Peptide

 Also Known As   

DIO2 Immunizing Peptide

 Product Synonym Names    DIO2; deiodinase, iodothyronine, type II; 5DII; D2; SelY; TXDI2; thyroxine deiodinase, type II; type 2 iodothyronine deiodinase; type II iodothyronine deiodinaseN: type-II 5'deiodinase
 Product Gene Name   

DIO2 peptide

[Similar Products]
 Antibody/Peptide Pairs    DIO2 peptide (MBS425448) is used for blocking the activity of DIO2 antibody (MBS421525)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    EVKKHQNQED RC
 OMIM    601413
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 Species Reactivity    Human, Mouse, Rat, Pig
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of DIO2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for DIO2. It may not necessarily be applicable to this product.
 NCBI GI #    7549805
 NCBI GeneID    1734
 NCBI Accession #    NP_000784.2 [Other Products]
 NCBI Related Accession #    NP_054644.1; NP_001007024.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000793.5 [Other Products]
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 UniProt Secondary Accession #    Q6B0A3; Q9HCP8; Q9P1W4; Q9UDZ1; B9EGK0; G3V315 [Other Products]
 UniProt Related Accession #    Q92813 [Other Products]
 Molecular Weight    34,704 Da
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 NCBI Official Full Name    type II iodothyronine deiodinase isoform a
 NCBI Official Synonym Full Names    deiodinase, iodothyronine, type II
 NCBI Official Symbol    DIO2 [Similar Products]
 NCBI Official Synonym Symbols   
D2; 5DII; SelY; DIOII; TXDI2
[Similar Products]
 NCBI Protein Information    type II iodothyronine deiodinase
 UniProt Protein Name    Type II iodothyronine deiodinase
 UniProt Synonym Protein Names   
5DII; DIOII; Type 2 DI; Type-II 5'-deiodinase
 Protein Family    Type II iodothyronine deiodinase
 UniProt Gene Name    DIO2 [Similar Products]
 UniProt Synonym Gene Names    ITDI2; TXDI2 [Similar Products]
 UniProt Entry Name    IOD2_HUMAN
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 NCBI Summary for DIO2    The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is widely expressed, including in thyroid, placenta, pituitary and brain. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. It has also been reported to be highly expressed in thyroids of patients with Graves disease, and in follicular adenomas. The intrathyroidal T4 to T3 conversion by this enzyme may contribute significantly to the relative increase in thyroidal T3 production in these patients. This protein is a selenoprotein containing the rare selenocysteine (Sec) amino acid at its active site, and may contain additional Sec residues. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2016]
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 UniProt Comments for DIO2    DIO2: Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. Belongs to the iodothyronine deiodinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Oxidoreductase; EC 1.97.1.10

Chromosomal Location of Human Ortholog: 14q24.2-q24.3

Cellular Component: integral to membrane; membrane; plasma membrane

Molecular Function: selenium binding; thyroxine 5'-deiodinase activity; ubiquitin protein ligase binding

Biological Process: hormone biosynthetic process; selenocysteine incorporation; thyroid hormone generation; thyroid hormone metabolic process
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 Research Articles on DIO2    1. Data provide evidence in humans that genetic predisposition combined with early osteoarthritis-related changes results in loff of epigenetic silencing of DIO2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with DIO2 peptideDiseases associated with DIO2 peptide
 Products by Pathway  Pathway Diagram
 Amine-derived Hormones Pathway antibodies  Amine-derived Hormones Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Regulation Of Thyroid Hormone Activity Pathway antibodies  Regulation Of Thyroid Hormone Activity Pathway Diagram
 Selenium Metabolism And Selenoproteins Pathway antibodies  Selenium Metabolism And Selenoproteins Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
 Thyroid Hormone Signaling Pathway antibodies  Thyroid Hormone Signaling Pathway Diagram
 Thyroxine Biosynthesis Pathway antibodies  Thyroxine Biosynthesis Pathway Diagram
 Thyroid Hormone Metabolism I (via Deiodination) Pathway antibodies  Thyroid Hormone Metabolism I (via Deiodination) Pathway Diagram
 Thyroid Hormone Metabolism I (via Deiodination) Pathway antibodies  Thyroid Hormone Metabolism I (via Deiodination) Pathway Diagram
 Disease Name  Pubmed Publications
 Thyroid Diseases Antibodies  >36 publications with DIO2 and Thyroid Diseases
 Inflammation Antibodies  >11 publications with DIO2 and Inflammation
 Nervous System Diseases Antibodies  >10 publications with DIO2 and Nervous System Diseases
 Hypertension Antibodies  >8 publications with DIO2 and Hypertension
 Hypertrophy Antibodies  >6 publications with DIO2 and Hypertrophy
 Fatty Liver Antibodies  >5 publications with DIO2 and Fatty Liver
 Kidney Diseases Antibodies  >5 publications with DIO2 and Kidney Diseases
 Weight Loss Antibodies  >5 publications with DIO2 and Weight Loss
 Prenatal Exposure Delayed Effects Antibodies  >4 publications with DIO2 and Prenatal Exposure Delayed Effects
 Liver Diseases Antibodies  >4 publications with DIO2 and Liver Diseases
Organs/Tissues associated with DIO2 peptide
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >214 publications with DIO2 and Thyroid
 Brain Antibodies  >103 publications with DIO2 and Brain
 Liver Antibodies  >43 publications with DIO2 and Liver
 Connective Tissue Antibodies  >41 publications with DIO2 and Connective Tissue
 Pituitary Gland Antibodies  >39 publications with DIO2 and Pituitary Gland
 Muscle Antibodies  >34 publications with DIO2 and Muscle
 Bone Antibodies  >17 publications with DIO2 and Bone
 Testis Antibodies  >13 publications with DIO2 and Testis
 Kidney Antibodies  >13 publications with DIO2 and Kidney
 Embryonic Tissue Antibodies  >10 publications with DIO2 and Embryonic Tissue
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