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DACH2 peptide :: Dachshund homolog 2 / DACH2 Peptide

Scan QR to view Datasheet Catalog #    MBS426947 DACH2 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Dachshund homolog 2 / DACH2, Peptide

 Also Known As   

Dachshund homolog 2 / DACH2 Immunizing Peptide

 Product Synonym Names    DACH2; dachshund homolog 2 (Drosophila); RP11-345E19.1; FLJ31391; MGC138545; dachshund 2; Dachshund homolog 2; Dachshund homolog 2 / DACH2
 Product Gene Name   

DACH2 peptide

[Similar Products]
 Antibody/Peptide Pairs    Dachshund homolog 2 / DACH2 peptide (MBS426947) is used for blocking the activity of Dachshund homolog 2/DACH2 antibody (MBS421612)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-TRKQAVNS SRPGR
 OMIM    300608
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 Species Reactivity    Human, Mouse
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of DACH2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for DACH2. It may not necessarily be applicable to this product.
 NCBI GI #    16876441
 NCBI GeneID    117154
 NCBI Accession #    NP_444511.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_053281.3 [Other Products]
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 UniProt Secondary Accession #    Q8NAY3; Q8ND17; Q96N55; B1AJV3; B4DQG3 [Other Products]
 UniProt Related Accession #    Q96NX9 [Other Products]
 Molecular Weight    47,156 Da
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 NCBI Official Full Name    dachshund homolog 2 isoform a
 NCBI Official Synonym Full Names    dachshund family transcription factor 2
 NCBI Official Symbol    DACH2 [Similar Products]
 NCBI Protein Information    dachshund homolog 2
 UniProt Protein Name    Dachshund homolog 2
 Protein Family    Dachshund
 UniProt Gene Name    DACH2 [Similar Products]
 UniProt Synonym Gene Names    Dach2 [Similar Products]
 UniProt Entry Name    DACH2_HUMAN
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 NCBI Summary for DACH2    This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
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 UniProt Comments for DACH2    DACH2: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression. Probably binds to DNA via its DACHbox-N domain. Belongs to the DACH/dachshund family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: Xq21.3

Cellular Component: nucleus; transcription factor complex

Molecular Function: DNA binding

Biological Process: development of primary female sexual characteristics; multicellular organismal development; regulation of transcription, DNA-dependent; transcriptional preinitiation complex assembly
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 Research Articles on DACH2    1. Exome sequencing in two brothers with distinct phenotype including congenital language disorder, growth retardation, intellectual disability and urinary and fecal incontinence, identifies missense mutations in ABCD1 and DACH2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DACH2 peptideDiseases associated with DACH2 peptide
 Reference Product  PubMed Publications
 SIX1 peptide  >6 publications with DACH2 and SIX1
 PAX3 peptide  >4 publications with DACH2 and PAX3
 EYA2 peptide  >3 publications with DACH2 and EYA2
 SIX6 peptide  >2 publications with DACH2 and SIX6
 PAX6 peptide  >2 publications with DACH2 and PAX6
 EYA1 peptide  >2 publications with DACH2 and EYA1
 NCOR1 peptide  >1 publications with DACH2 and NCOR1
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >2 publications with DACH2 and Congenital Abnormalities
 Atrophy Antibodies  >1 publications with DACH2 and Atrophy
 Breast Neoplasms Antibodies  >1 publications with DACH2 and Breast Neoplasms
 Eye Abnormalities Antibodies  >1 publications with DACH2 and Eye Abnormalities
 Musculoskeletal Abnormalities Antibodies  >1 publications with DACH2 and Musculoskeletal Abnormalities
 Ovarian Neoplasms Antibodies  >1 publications with DACH2 and Ovarian Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with DACH2 and Neoplasm Metastasis
Organs/Tissues associated with DACH2 peptide
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >13 publications with DACH2 and Muscle
 Brain Antibodies  >9 publications with DACH2 and Brain
 Embryonic Tissue Antibodies  >8 publications with DACH2 and Embryonic Tissue
 Kidney Antibodies  >1 publications with DACH2 and Kidney
 Testis Antibodies  >1 publications with DACH2 and Testis
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