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EBI3 peptide

Scan QR to view Datasheet Catalog #    MBS425046 EBI3 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

EBI3, Peptide

 Also Known As   

EBI3 Immunizing Peptide

 Product Synonym Names    EBI3; Epstein-Barr virus induced gene 3
 Product Gene Name   

EBI3 peptide

[Similar Products]
 Antibody/Peptide Pairs    EBI3 peptide (MBS425046) is used for blocking the activity of EBI3 antibody (MBS421799)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-IRYKRQGA ARFHR
 OMIM    605816
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 Species Reactivity    Human
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of EBI3 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for EBI3. It may not necessarily be applicable to this product.
 NCBI GI #    14577917
 NCBI GeneID    10148
 NCBI Accession #    NP_005746.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005755.2 [Other Products]
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 UniProt Secondary Accession #    O75269; A0N0N2 [Other Products]
 UniProt Related Accession #    Q14213 [Other Products]
 Molecular Weight    25,396 Da
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 NCBI Official Full Name    interleukin-27 subunit beta
 NCBI Official Synonym Full Names    Epstein-Barr virus induced 3
 NCBI Official Symbol    EBI3 [Similar Products]
 NCBI Official Synonym Symbols   
IL27B; IL-27B
[Similar Products]
 NCBI Protein Information    interleukin-27 subunit beta
 UniProt Protein Name    Interleukin-27 subunit beta
 UniProt Synonym Protein Names   
Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein
 Protein Family    Interleukin
 UniProt Gene Name    EBI3 [Similar Products]
 UniProt Synonym Gene Names    IL27B; IL-27 subunit beta; IL-27B; EBV-induced gene 3 protein [Similar Products]
 UniProt Entry Name    IL27B_HUMAN
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 NCBI Summary for EBI3    This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]
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 UniProt Comments for EBI3    IL27-beta: Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon- gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. Belongs to the type I cytokine receptor family. Type 3 subfamily.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular region; extracellular space; plasma membrane

Molecular Function: cytokine activity; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-27 receptor binding; protein binding

Biological Process: cytokine and chemokine mediated signaling pathway; humoral immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of interferon-gamma biosynthetic process; T cell proliferation; T-helper 1 type immune response
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 Research Articles on EBI3    1. Elevated circulating IL-35, particularly at early phase, its decrease after treatment initiation, and a positive association between synovial fluid IL-35 and disease activity support an involvement of IL-35 in the pathogenesis of RA.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with EBI3 peptidePathways associated with EBI3 peptide
 Reference Product  PubMed Publications
 IL27 peptide  >92 publications with EBI3 and IL27
 IL27RA peptide  >21 publications with EBI3 and IL27RA
 STAT1 peptide  >17 publications with EBI3 and STAT1
 STAT3 peptide  >16 publications with EBI3 and STAT3
 IL6ST peptide  >12 publications with EBI3 and IL6ST
 STAT4 peptide  >3 publications with EBI3 and STAT4
 JAK2 peptide  >1 publications with EBI3 and JAK2
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IL-6-type Cytokine Receptor Ligand Interactions Pathway antibodies  IL-6-type Cytokine Receptor Ligand Interactions Pathway Diagram
 IL27-mediated Signaling Events Pathway antibodies  IL27-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin-6 Family Signaling Pathway antibodies  Interleukin-6 Family Signaling Pathway Diagram
 Signaling By Interleukins Pathway antibodies  Signaling By Interleukins Pathway Diagram
Diseases associated with EBI3 peptideOrgans/Tissues associated with EBI3 peptide
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >70 publications with EBI3 and Inflammation
 Disease Models, Animal Antibodies  >38 publications with EBI3 and Disease Models, Animal
 Necrosis Antibodies  >18 publications with EBI3 and Necrosis
 Nervous System Diseases Antibodies  >15 publications with EBI3 and Nervous System Diseases
 Liver Diseases Antibodies  >14 publications with EBI3 and Liver Diseases
 Lung Diseases Antibodies  >11 publications with EBI3 and Lung Diseases
 Cardiovascular Diseases Antibodies  >10 publications with EBI3 and Cardiovascular Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >3 publications with EBI3 and Drug-Related Side Effects and Adverse Reactions
 Kidney Diseases Antibodies  >3 publications with EBI3 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >3 publications with EBI3 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >14 publications with EBI3 and Lymph Node
 Eye Antibodies  >7 publications with EBI3 and Eye
 Placenta Antibodies  >4 publications with EBI3 and Placenta
 Brain Antibodies  >3 publications with EBI3 and Brain
 Tonsil Antibodies  >3 publications with EBI3 and Tonsil
 Uterus Antibodies  >3 publications with EBI3 and Uterus
 Embryonic Tissue Antibodies  >2 publications with EBI3 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with EBI3 and Pancreas
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