NP_001138497.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,319 Da
NCBI Official Full Name
ER degradation-enhancing alpha-mannosidase-like protein 2 isoform 2
NCBI Official Synonym Full Names
ER degradation enhancer, mannosidase alpha-like 2
NCBI Protein Information
ER degradation-enhancing alpha-mannosidase-like protein 2
UniProt Protein Name
ER degradation-enhancing alpha-mannosidase-like protein 2
UniProt Synonym Gene Names
UniProt Entry Name
EDEM2_HUMAN
NCBI Summary for EDEM2
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM, Mar 2008]
UniProt Comments for EDEM2
EDEM2: Involved in endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity. Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. Belongs to the glycosyl hydrolase 47 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 20q11.22
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen; extracellular region
Molecular Function: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; calcium ion binding
Biological Process: cellular protein metabolic process; protein folding; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; response to unfolded protein
Research Articles on EDEM2
Precautions
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Products associated with EDEM2 peptide
Pathways associated with EDEM2 peptide
Diseases associated with EDEM2 peptide
Organs/Tissues associated with EDEM2 peptide
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