NP_079467.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
102,005 Da
NCBI Official Full Name
ER degradation-enhancing alpha-mannosidase-like protein 3
NCBI Official Synonym Full Names
ER degradation enhancer, mannosidase alpha-like 3
NCBI Official Synonym Symbols
NCBI Protein Information
ER degradation-enhancing alpha-mannosidase-like protein 3
UniProt Protein Name
ER degradation-enhancing alpha-mannosidase-like protein 3
UniProt Synonym Protein Names
Alpha-1,2-mannosidase EDEM3
UniProt Synonym Gene Names
UniProt Entry Name
EDEM3_HUMAN
NCBI Summary for EDEM3
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008]
UniProt Comments for EDEM3
EDEM3: Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes. This process depends on mannose-trimming from the N-glycans. Seems to have alpha 1,2-mannosidase activity. Belongs to the glycosyl hydrolase 47 family.
Protein type: EC 3.2.1.113; Hydrolase
Chromosomal Location of Human Ortholog: 1q25
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen
Molecular Function: glycoprotein endo-alpha-1,2-mannosidase activity; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; calcium ion binding
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; cellular protein metabolic process; protein folding; protein amino acid N-linked glycosylation via asparagine; glycoprotein catabolic process; post-translational protein modification; response to unfolded protein
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Products associated with EDEM3 peptide
Pathways associated with EDEM3 peptide
Diseases associated with EDEM3 peptide
Organs/Tissues associated with EDEM3 peptide
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