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ERC1 peptide :: ELKS / RAB6IP2 Peptide

Scan QR to view Datasheet Catalog #    MBS425021 ERC1 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ELKS / RAB6IP2 (ERC1), Peptide

 Also Known As   

ELKS / RAB6IP2 Immunizing Peptide

 Product Synonym Names    ERC1; ELKS/RAB6-interacting/CAST family member 1; Cast2; ELKS; KIAA1081; MGC12974; RAB6IP2; RAB6 interacting protein 2; RAB6-interacting protein 2; Rab6-interacting protein 2; FLJ31750; OTTHUMP00000160633; ELKS / RAB6IP2
 Product Gene Name   

ERC1 peptide

[Similar Products]
 Product Synonym Gene Name    ELKS; RAB6IP2 [Similar Products]
 Antibody/Peptide Pairs    ELKS / RAB6IP2 peptide (MBS425021) is used for blocking the activity of ELKS/RAB6IP2 antibody (MBS421405)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607127
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 Species Reactivity    Human, Mouse, Rat, Dog, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of ERC1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ERC1. It may not necessarily be applicable to this product.
 NCBI GI #    38045896
 NCBI GeneID    23085
 NCBI Accession #    NP_829883.1 [Other Products]
 NCBI Related Accession #    NP_829884.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_178039.3 [Other Products]
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 UniProt Secondary Accession #    Q6NVK2; Q8IUD3; Q8IUD4; Q8IUD5; Q8NAS1; Q9NXN5; Q9UIK7; A2RU77; A7E295; D3DUP7; D3DUP8 [Other Products]
 UniProt Related Accession #    Q8IUD2 [Other Products]
 Molecular Weight    81,967 Da
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 NCBI Official Full Name    ELKS/Rab6-interacting/CAST family member 1 isoform delta
 NCBI Official Synonym Full Names    ELKS/RAB6-interacting/CAST family member 1
 NCBI Official Symbol    ERC1 [Similar Products]
 NCBI Official Synonym Symbols   
ELKS; Cast2; ERC-1; RAB6IP2
[Similar Products]
 NCBI Protein Information    ELKS/Rab6-interacting/CAST family member 1
 UniProt Protein Name    ELKS/Rab6-interacting/CAST family member 1
 UniProt Synonym Protein Names   
Rab6-interacting protein 2
 Protein Family    ELKS/Rab6-interacting/CAST family
 UniProt Gene Name    ERC1 [Similar Products]
 UniProt Synonym Gene Names    ELKS; KIAA1081; RAB6IP2; ERC-1 [Similar Products]
 UniProt Entry Name    RB6I2_HUMAN
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 NCBI Summary for ERC1    The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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 UniProt Comments for ERC1    ERC1: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. Part of a complex with CHUK, IKBKB and IKBKG. Interacts with CHUK, IKBKB and IKBKG. The interaction with IKBKG is independent of CHUK and IKBKB. Interacts with NFKBIA. Isoform 4 interacts with PPFIA1, and through its C-terminus with the PDZ domains of RIMS1 and RIMS2. Interacts with ERC2/CAST1. Interacts with the GTB-bound forms of RAB6A isoform 1 and isoform 2 and with RAB6B. The interaction was strongest with RAB6B, followed by RAB6A isoform 2 and weakest with RAB6A isoform 1. Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: cytoplasm; Golgi membrane; IkappaB kinase complex; presynaptic active zone; presynaptic membrane; synapse

Molecular Function: leucine zipper domain binding; PDZ domain binding; protein binding; Rab GTPase binding

Biological Process: activation of NF-kappaB transcription factor; I-kappaB phosphorylation; multicellular organismal development; protein transport; regulation of transcription, DNA-dependent; retrograde transport, endosome to Golgi
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 Research Articles on ERC1    1. Liprin-alpha1, ERC1a and LL5 also define new highly polarized and dynamic cytoplasmic structures uniquely localized near the protruding cell edge
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ERC1 peptidePathways associated with ERC1 peptide
 Reference Product  PubMed Publications
 BSN peptide  >6 publications with ERC1 and BSN
 IKBKB peptide  >3 publications with ERC1 and IKBKB
 IKBKG peptide  >3 publications with ERC1 and IKBKG
 RELA peptide  >1 publications with ERC1 and RELA
 NFKBIA peptide  >1 publications with ERC1 and NFKBIA
 CHUK peptide  >1 publications with ERC1 and CHUK
 Products by Pathway  Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 IL1-mediated Signaling Events Pathway antibodies  IL1-mediated Signaling Events Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
Diseases associated with ERC1 peptideOrgans/Tissues associated with ERC1 peptide
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >3 publications with ERC1 and Carcinoma
 Neoplasms, Experimental Antibodies  >3 publications with ERC1 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >2 publications with ERC1 and Kidney Diseases
 Liver Neoplasms Antibodies  >2 publications with ERC1 and Liver Neoplasms
 Breast Neoplasms Antibodies  >2 publications with ERC1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >2 publications with ERC1 and Lung Neoplasms
 Necrosis Antibodies  >2 publications with ERC1 and Necrosis
 Adenocarcinoma Antibodies  >1 publications with ERC1 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >1 publications with ERC1 and Neoplasm Metastasis
 Liver Neoplasms, Experimental Antibodies  >1 publications with ERC1 and Liver Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with ERC1 and Brain
 Blood Antibodies  >5 publications with ERC1 and Blood
 Liver Antibodies  >3 publications with ERC1 and Liver
 Muscle Antibodies  >3 publications with ERC1 and Muscle
 Bone Antibodies  >2 publications with ERC1 and Bone
 Lung Antibodies  >2 publications with ERC1 and Lung
 Kidney Antibodies  >2 publications with ERC1 and Kidney
 Thyroid Antibodies  >1 publications with ERC1 and Thyroid
 Embryonic Tissue Antibodies  >1 publications with ERC1 and Embryonic Tissue
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