NP_036139.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,259 Da
NCBI Official Full Name
SH2 domain protein 1B
NCBI Official Synonym Full Names
SH2 domain containing 1B1
NCBI Official Synonym Symbols
Eat2; EAT-2; Eat2a; EAT-2A; Sh2d1b [Similar Products]
NCBI Protein Information
SH2 domain-containing protein 1B
UniProt Protein Name
SH2 domain-containing protein 1B
UniProt Synonym Protein Names
EWS/FLI1-activated transcript 2; EAT-2
UniProt Synonym Gene Names
UniProt Entry Name
SH21B_MOUSE
UniProt Comments for Sh2d1b
SH2D1B: Plays a role in controlling signal transduction through at least four receptors, CD84, SLAMF1, LY9 and CD244, expressed on the surface of professional antigen-presenting cells. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Cellular Component: intracellular
Molecular Function: phosphotyrosine binding; protein binding
Biological Process: adaptive immune response; immune system process; innate immune response; leukocyte activation during immune response; natural killer cell inhibitory signaling pathway; negative regulation of interferon-gamma production; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of peptidyl-tyrosine phosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of innate immune response; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated immunity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of signal transduction
Research Articles on Sh2d1b
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Pathways associated with Sh2d1b blocking peptide
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