NP_001161791.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
endothelin-1 isoform 2 preproprotein
NCBI Official Synonym Full Names
endothelin 1
NCBI Official Synonym Symbols
ET1; QME; PPET1; ARCND3; HDLCQ7 [Similar Products]
NCBI Protein Information
endothelin-1
UniProt Protein Name
Endothelin-1
UniProt Synonym Protein Names
Preproendothelin-1; PPET1
UniProt Synonym Gene Names
UniProt Entry Name
EDN1_HUMAN
NCBI Summary for EDN1
This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
UniProt Comments for EDN1
EDN1: Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 6p24.1
Cellular Component: cytoplasm; extracellular region; extracellular space
Molecular Function: cytokine activity; endothelin A receptor binding; endothelin B receptor binding; hormone activity; protein binding
Biological Process: artery smooth muscle contraction; body fluid secretion; calcium-mediated signaling; cartilage development; cell growth; cell surface receptor linked signal transduction; cell-cell signaling; dorsal/ventral pattern formation; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); epithelial fluid transport; G-protein coupled receptor protein signaling pathway; G-protein signaling, phospholipase D activating pathway; glucose transport; heart development; histamine secretion; in utero embryonic development; inositol phosphate-mediated signaling; leukocyte activation; maternal process involved in parturition; membrane depolarization; middle ear morphogenesis; multicellular organismal aging; negative regulation of blood coagulation; negative regulation of cAMP biosynthetic process; negative regulation of cellular protein metabolic process; negative regulation of hormone secretion; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; neural crest cell development; neutrophil chemotaxis; nitric oxide transport; patterning of blood vessels; peptide hormone secretion; phosphoinositide 3-kinase cascade; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell size; positive regulation of heart rate; positive regulation of hormone secretion; positive regulation of JNK activity; positive regulation of MAP kinase activity; positive regulation of mitosis; positive regulation of nitric oxide biosynthetic process; positive regulation of odontogenesis; positive regulation of prostaglandin secretion; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle contraction; positive regulation of transcription from RNA polymerase II promoter; prostaglandin biosynthetic process; protein kinase C activation; protein kinase C deactivation; regulation of pH; regulation of sensory perception of pain; regulation of systemic arterial blood pressure by endothelin; regulation of vasoconstriction; respiratory gaseous exchange; response to activity; response to amino acid stimulus; response to lipopolysaccharide; response to nicotine; response to ozone; response to testosterone stimulus; rhythmic excitation; sensory perception of pain; superoxide release; vasoconstriction; vein smooth muscle contraction
Disease: Auriculocondylar Syndrome 3; Question Mark Ears, Isolated
Research Articles on EDN1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with EDN1 peptide
Diseases associated with EDN1 peptide
Organs/Tissues associated with EDN1 peptide
|