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F11R peptide :: F11R / JAM-A Peptide

Scan QR to view Datasheet Catalog #    MBS425770 F11R peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

F11R / JAM-A, Peptide

 Also Known As   

F11R / JAM-A Immunizing Peptide

 Product Synonym Names    F11R; F11 receptor; CD321; JAM; JAM-1; JAM-A; JAM1; JAMA; JCAM; KAT; PAM-1; OTTHUMP00000027880; OTTHUMP00000027881; junctional adhesion molecule 1; junctional adhesion molecule A; platelet F11 receptor; platelet adhesion molecule; F11R / JAM-A
 Product Gene Name   

F11R peptide

[Similar Products]
 Product Synonym Gene Name    JAM-A [Similar Products]
 Antibody/Peptide Pairs    F11R / JAM-A peptide (MBS425770) is used for blocking the activity of F11R/JAM-A antibody (MBS421976)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-QPSARSEG EFKQTS
 OMIM    605721
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 Species Reactivity    Human, Mouse, Rat, Dog, Pig
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of F11R peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for F11R. It may not necessarily be applicable to this product.
 NCBI GI #    8393638
 NCBI GeneID    50848
 NCBI Accession #    NP_058642.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_016946.4 [Other Products]
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 UniProt Secondary Accession #    B7Z941 [Other Products]
 UniProt Related Accession #    Q9Y624 [Other Products]
 Molecular Weight    27,208 Da
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 NCBI Official Full Name    junctional adhesion molecule A
 NCBI Official Synonym Full Names    F11 receptor
 NCBI Official Symbol    F11R [Similar Products]
 NCBI Official Synonym Symbols   
JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1
[Similar Products]
 NCBI Protein Information    junctional adhesion molecule A
 UniProt Protein Name    Junctional adhesion molecule A
 UniProt Synonym Protein Names   
Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; CD_antigen: CD321
 Protein Family    Junctional adhesion molecule
 UniProt Gene Name    F11R [Similar Products]
 UniProt Synonym Gene Names    JAM1; JCAM; JAM-A; JAM-1; PAM-1 [Similar Products]
 UniProt Entry Name    JAM1_HUMAN
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 NCBI Summary for F11R    Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
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 UniProt Comments for F11R    JAM-A: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. Belongs to the immunoglobulin superfamily.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 1q21.2-q21.3

Cellular Component: cell junction; cytoplasmic vesicle; integral to membrane; intercellular junction; microtubule cytoskeleton; plasma membrane; tight junction

Molecular Function: PDZ domain binding; protein binding; viral receptor activity

Biological Process: actomyosin structure organization and biogenesis; cell adhesion; entry of virus into host cell; extracellular matrix organization and biogenesis; inflammatory response; intestinal absorption; leukocyte migration; positive regulation of blood pressure; positive regulation of GTPase activity; regulation of cytokine production; response to radiation; transforming growth factor beta receptor signaling pathway
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 Research Articles on F11R    1. JAM-A regulates the planar orientation of the mitotic spindle during epithelial morphogenesis. It triggers transient activation of Cdc42 and PI3K, generates a gradient of PtdIns(3,4,5)P3 at the cortex and regulates the formation of the actin cytoskeleton.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with F11R peptidePathways associated with F11R peptide
 Reference Product  PubMed Publications
 TJP1 peptide  >27 publications with F11R and TJP1
 CLDN1 peptide  >4 publications with F11R and CLDN1
 MLLT4 peptide  >2 publications with F11R and MLLT4
 ITGB2 peptide  >1 publications with F11R and ITGB2
 MPDZ peptide  >1 publications with F11R and MPDZ
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with F11R peptideOrgans/Tissues associated with F11R peptide
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >34 publications with F11R and Inflammation
 Breast Neoplasms Antibodies  >16 publications with F11R and Breast Neoplasms
 Carcinoma Antibodies  >14 publications with F11R and Carcinoma
 Disease Models, Animal Antibodies  >13 publications with F11R and Disease Models, Animal
 Necrosis Antibodies  >13 publications with F11R and Necrosis
 Neoplasm Metastasis Antibodies  >8 publications with F11R and Neoplasm Metastasis
 Heart Diseases Antibodies  >8 publications with F11R and Heart Diseases
 Adenocarcinoma Antibodies  >7 publications with F11R and Adenocarcinoma
 Neoplasm Invasiveness Antibodies  >7 publications with F11R and Neoplasm Invasiveness
 Lung Neoplasms Antibodies  >5 publications with F11R and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >76 publications with F11R and Blood
 Vascular Antibodies  >53 publications with F11R and Vascular
 Heart Antibodies  >18 publications with F11R and Heart
 Intestine Antibodies  >18 publications with F11R and Intestine
 Lung Antibodies  >15 publications with F11R and Lung
 Brain Antibodies  >15 publications with F11R and Brain
 Liver Antibodies  >12 publications with F11R and Liver
 Kidney Antibodies  >9 publications with F11R and Kidney
 Embryonic Tissue Antibodies  >9 publications with F11R and Embryonic Tissue
 Lymph Antibodies  >7 publications with F11R and Lymph
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