NP_060173.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,491 Da
NCBI Official Full Name
F-box/LRR-repeat protein 12 isoform a
NCBI Official Synonym Full Names
F-box and leucine-rich repeat protein 12
NCBI Official Synonym Symbols
NCBI Protein Information
F-box/LRR-repeat protein 12
UniProt Protein Name
F-box/LRR-repeat protein 12
UniProt Synonym Protein Names
F-box and leucine-rich repeat protein 12; F-box protein FBL12
UniProt Synonym Gene Names
UniProt Entry Name
FXL12_HUMAN
NCBI Summary for FBXL12
Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
UniProt Comments for FBXL12
FBXL12: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: cytoplasm; ubiquitin ligase complex
Molecular Function: protein binding
Biological Process: protein ubiquitination; ubiquitin-dependent protein catabolic process
Research Articles on FBXL12
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Organs/Tissues associated with FBXL12 blocking peptide
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