NP_001442.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,122 Da
NCBI Official Full Name
forkhead box protein F1
NCBI Official Synonym Full Names
forkhead box F1
NCBI Protein Information
forkhead box protein F1
UniProt Protein Name
Forkhead box protein F1
UniProt Synonym Protein Names
Forkhead-related activator 1; FREAC-1; Forkhead-related protein FKHL5; Forkhead-related transcription factor 1
UniProt Synonym Gene Names
UniProt Entry Name
FOXF1_HUMAN
NCBI Summary for FOXF1
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]
UniProt Comments for FOXF1
FOXF1: Probable transcription activator for a number of lung- specific genes. Defects in FOXF1 are the cause of alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV). ACDMPV is a rare malformation due to abnormal development of the capillary vascular system in the lungs. Histologically, it is characterized by failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.
Protein type: Motility/polarity/chemotaxis; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 16q24
Cellular Component: nucleus; transcription factor complex
Molecular Function: DNA binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding
Biological Process: alveolus development; blood vessel development; cell-cell adhesion; detection of wounding; determination of left/right symmetry; embryonic digestive tract morphogenesis; embryonic ectodermal gut morphogenesis; embryonic foregut morphogenesis; establishment of epithelial cell polarity; extracellular matrix organization and biogenesis; gut development; heart development; in utero embryonic development; lateral mesodermal cell differentiation; lung development; midgut development; morphogenesis of a branching structure; negative regulation of inflammatory response; negative regulation of mast cell degranulation; negative regulation of transcription from RNA polymerase II promoter; pancreas development; positive regulation of cell migration; positive regulation of mesenchymal cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of smooth muscle cell differentiation; respiratory tube development; smooth muscle cell differentiation; smoothened signaling pathway; somitogenesis; transcription from RNA polymerase II promoter; vasculogenesis
Disease: Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Research Articles on FOXF1
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Pathways associated with FOXF1 blocking peptide
Diseases associated with FOXF1 blocking peptide
Organs/Tissues associated with FOXF1 blocking peptide
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