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FTL peptide

Scan QR to view Datasheet Catalog #    MBS426708 FTL peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FTL, Peptide

 Also Known As   

FTL Immunizing Peptide

 Product Synonym Names    FTL; ferritin, light polypeptide; MGC71996; L apoferritin; ferritin L subunit; ferritin L-chain; ferritin light chain; ferritin light polypeptide-like 3
 Product Gene Name   

FTL peptide

[Similar Products]
 Antibody/Peptide Pairs    FTL peptide (MBS426708) is used for blocking the activity of FTL antibody (MBS422205)
 Antibody/Peptide Pairs    FTL peptide (MBS426708) is used for blocking the activity of FTL antibody (MBS423636)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-GEYLFERL TLKHD
 OMIM    134790
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 Species Reactivity    Human, Mouse, Rat, Dog, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of FTL peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for FTL. It may not necessarily be applicable to this product.
 NCBI GI #    20149498
 NCBI GeneID    2512
 NCBI Accession #    NP_000137.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000146.3 [Other Products]
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 UniProt Secondary Accession #    Q6IBT7; Q7Z2W1; Q86WI9; Q8WU07; Q96AU9; Q96CU0; Q9BTZ8; B2R4B9 [Other Products]
 UniProt Related Accession #    P02792 [Other Products]
 Molecular Weight    20,020 Da
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 NCBI Official Full Name    ferritin light chain
 NCBI Official Synonym Full Names    ferritin, light polypeptide
 NCBI Official Symbol    FTL [Similar Products]
 NCBI Official Synonym Symbols   
LFTD; NBIA3
[Similar Products]
 NCBI Protein Information    ferritin light chain
 UniProt Protein Name    Ferritin light chain
 Protein Family    Ferritin
 UniProt Gene Name    FTL [Similar Products]
 UniProt Synonym Gene Names    Ferritin L subunit [Similar Products]
 UniProt Entry Name    FRIL_HUMAN
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 NCBI Summary for FTL    This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FTL    FTL: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS). It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene. Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3); also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels. Belongs to the ferritin family.

Protein type: Oxidoreductase

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: cytosol; ferritin complex; membrane

Molecular Function: ferric iron binding; identical protein binding; iron ion binding; protein binding

Biological Process: cellular iron ion homeostasis; iron ion homeostasis; iron ion transport

Disease: Hyperferritinemia With Or Without Cataract; L-ferritin Deficiency; Neurodegeneration With Brain Iron Accumulation 3
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 Research Articles on FTL    1. Studies indicate that the the best characterized cytosolic ferritins in mammals are encoded by two genes, FTH and FTL, with four exons and similar structures.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FTL peptidePathways associated with FTL peptide
 Reference Product  PubMed Publications
 FTH1 peptide  >14 publications with FTL and FTH1
 PSENEN peptide  >1 publications with FTL and PSENEN
 HSPA8 peptide  >1 publications with FTL and HSPA8
 FECH peptide  >1 publications with FTL and FECH
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Scavenging By Class A Receptors Pathway antibodies  Scavenging By Class A Receptors Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
Diseases associated with FTL peptideOrgans/Tissues associated with FTL peptide
 Disease Name  Pubmed Publications
 Iron Metabolism Disorders Antibodies  >48 publications with FTL and Iron Metabolism Disorders
 Nervous System Diseases Antibodies  >42 publications with FTL and Nervous System Diseases
 Brain Diseases Antibodies  >36 publications with FTL and Brain Diseases
 Neuroferritinopathy Antibodies  >30 publications with FTL and Neuroferritinopathy
 Inflammation Antibodies  >15 publications with FTL and Inflammation
 Hyperferritinemia, hereditary, with congenital cataracts Antibodies  >10 publications with FTL and Hyperferritinemia, hereditary, with congenital cataracts
 Breast Neoplasms Antibodies  >9 publications with FTL and Breast Neoplasms
 Heredodegenerative Disorders, Nervous System Antibodies  >8 publications with FTL and Heredodegenerative Disorders, Nervous System
 Cognition Disorders Antibodies  >6 publications with FTL and Cognition Disorders
 Liver Diseases Antibodies  >6 publications with FTL and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >70 publications with FTL and Brain
 Blood Antibodies  >59 publications with FTL and Blood
 Liver Antibodies  >24 publications with FTL and Liver
 Eye Antibodies  >17 publications with FTL and Eye
 Nerve Antibodies  >16 publications with FTL and Nerve
 Heart Antibodies  >12 publications with FTL and Heart
 Muscle Antibodies  >10 publications with FTL and Muscle
 Vascular Antibodies  >10 publications with FTL and Vascular
 Spleen Antibodies  >10 publications with FTL and Spleen
 Lung Antibodies  >10 publications with FTL and Lung
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