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F13A1 peptide :: Factor XIIIa (703-717) Peptide

Scan QR to view Datasheet Catalog #    MBS427440 F13A1 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Factor XIIIa (703-717) (F13A1), Peptide

 Also Known As   

Factor XIIIa (703-717) Immunizing Peptide

 Product Synonym Names    Goat Anti-Factor XIIIa (49-62) Antibody; factor XIIIa antibody; F13A1 antibody; coagulation factor XIII; A1 polypeptide antibody; RP11-232H4.1 antibody; F13A antibody; Coagulation factor XIII A chain antibody; Coagulation factor XIII; A polypeptide antibody; TGase antibody; bA525O21.1 (coagulation factor XIII; A1 polypeptide) antibody; coagulation factor XIII A1 subunit antibody
 Product Gene Name   

F13A1 peptide

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-TSVHLFKE RWDTNK
 Chromosome Location    Chromosome: 6; NC_000006.11 (6144311..6320924, complement). Location: 6p25.3-p24.3
 OMIM    134570
 3D Structure    ModBase 3D Structure for P00488
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 Species Reactivity    Tested: Human
Expected: Mouse
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of F13A1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for F13A1. It may not necessarily be applicable to this product.
 NCBI GI #    119395709
 NCBI GeneID    2162
 NCBI Accession #    NP_000120.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000129.3 [Other Products]
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 UniProt Primary Accession #    P00488 [Other Products]
 UniProt Secondary Accession #    Q59HA7; Q8N6X2; Q96P24; Q9BX29 [Other Products]
 UniProt Related Accession #    P00488 [Other Products]
 Molecular Weight    83,267 Da
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 NCBI Official Full Name    coagulation factor XIII A chain
 NCBI Official Synonym Full Names    coagulation factor XIII, A1 polypeptide
 NCBI Official Symbol    F13A1 [Similar Products]
 NCBI Official Synonym Symbols   
F13A
[Similar Products]
 NCBI Protein Information    coagulation factor XIII A chain; TGase; factor XIIIa; fibrinoligase; FSF, A subunit; coagulation factor XIIIa; transglutaminase A chain; transglutaminase. plasma; fibrin stabilizing factor, A subunit; coagulation factor XIII, A polypeptide; protein-glutamine gamma-glutamyltransferase A chain; bA525O21.1 (coagulation factor XIII, A1 polypeptide)
 UniProt Protein Name    Coagulation factor XIII A chain
 UniProt Synonym Protein Names   
Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain
 Protein Family    Coagulation factor
 UniProt Gene Name    F13A1 [Similar Products]
 UniProt Synonym Gene Names    F13A; Coagulation factor XIIIa [Similar Products]
 UniProt Entry Name    F13A_HUMAN
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 NCBI Summary for F13A1    This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
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 UniProt Comments for F13A1    Function: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Catalytic activity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactor: Binds 1 calcium ion per subunit.

Subunit structure: Tetramer of two A chains and two B chains.

Subcellular location: Cytoplasm. Secreted. Note: Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.

Post-translational modification: The activation peptide is released by thrombin.

Polymorphism: There are four main allelic forms of this protein; F13A*1A, F13A*1B, F13A*2A and F13A*2B. In addition two other intermediate forms (F13A*2A and F13A*2B) seem to exist. The sequence shown is that of F13A*2B.

Involvement in disease: Factor XIII subunit A deficiency (FA13AD) [MIM:613225]: An autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.16

Sequence similarities: Belongs to the transglutaminase superfamily. Transglutaminase family.

Sequence caution: The sequence AAA52489.1 differs from that shown. Reason: Erroneous initiation. The sequence BAD92089.1 differs from that shown. Reason: Erroneous initiation.
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 Research Articles on F13A1    1. The activation peptide cleft exposed by thrombin cleavage of FXIII-A(2) contains a recognition site for the fibrinogen alpha chain.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with F13A1 peptidePathways associated with F13A1 peptide
 Reference Product  PubMed Publications
 FGA peptide  >9 publications with F13A1 and FGA
 F13B peptide  >8 publications with F13A1 and F13B
 FGG peptide  >3 publications with F13A1 and FGG
 Products by Pathway  Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
Diseases associated with F13A1 peptideOrgans/Tissues associated with F13A1 peptide
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >12 publications with F13A1 and Cardiovascular Diseases
 Factor XIII Deficiency Antibodies  >7 publications with F13A1 and Factor XIII Deficiency
 Brain Diseases Antibodies  >6 publications with F13A1 and Brain Diseases
 Heart Diseases Antibodies  >6 publications with F13A1 and Heart Diseases
 Inflammation Antibodies  >4 publications with F13A1 and Inflammation
 Neoplasms Antibodies  >3 publications with F13A1 and Neoplasms
 Myocardial Infarction Antibodies  >3 publications with F13A1 and Myocardial Infarction
 Anemia Antibodies  >2 publications with F13A1 and Anemia
 Atherosclerosis Antibodies  >2 publications with F13A1 and Atherosclerosis
 Venous Thrombosis Antibodies  >2 publications with F13A1 and Venous Thrombosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >29 publications with F13A1 and Blood
 Bone Antibodies  >4 publications with F13A1 and Bone
 Kidney Antibodies  >3 publications with F13A1 and Kidney
 Heart Antibodies  >3 publications with F13A1 and Heart
 Prostate Antibodies  >3 publications with F13A1 and Prostate
 Adipose Tissue Antibodies  >2 publications with F13A1 and Adipose Tissue
 Bone Marrow Antibodies  >2 publications with F13A1 and Bone Marrow
 Lymph Node Antibodies  >1 publications with F13A1 and Lymph Node
 Connective Tissue Antibodies  >1 publications with F13A1 and Connective Tissue
 Eye Antibodies  >1 publications with F13A1 and Eye
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