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FZD2 peptide :: Frizzled 2 Peptide

Scan QR to view Datasheet Catalog #    MBS426257 FZD2 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Frizzled 2 (FZD2), Peptide

 Also Known As   

Frizzled 2 Immunizing Peptide

 Product Synonym Names    FZD2; frizzled homolog 2 (Drosophila); frizzled 2; Frizzled 2; Frizzled 2
 Product Gene Name   

FZD2 peptide

[Similar Products]
 Antibody/Peptide Pairs    Frizzled 2 peptide (MBS426257) is used for blocking the activity of Frizzled 2 antibody (MBS421771)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    RYATLEHPFH CPR
 OMIM    600667
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 Species Reactivity    Human, Mouse, Rat
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of FZD2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for FZD2. It may not necessarily be applicable to this product.
 NCBI GI #    4503827
 NCBI GeneID    2535
 NCBI Accession #    NP_001457.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001466.3 [Other Products]
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 UniProt Secondary Accession #    Q0VG82 [Other Products]
 UniProt Related Accession #    Q14332 [Other Products]
 Molecular Weight    63,554 Da
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 NCBI Official Full Name    frizzled-2
 NCBI Official Synonym Full Names    frizzled class receptor 2
 NCBI Official Symbol    FZD2 [Similar Products]
 NCBI Official Synonym Symbols   
Fz2; fz-2; fzE2; hFz2
[Similar Products]
 NCBI Protein Information    frizzled-2
 UniProt Protein Name    Frizzled-2
 UniProt Synonym Protein Names   
FzE2
 UniProt Gene Name    FZD2 [Similar Products]
 UniProt Synonym Gene Names    Fz-2; hFz2 [Similar Products]
 UniProt Entry Name    FZD2_HUMAN
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 NCBI Summary for FZD2    This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]
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 UniProt Comments for FZD2    FZD2: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, integral; GPCR, Fz/Smo family

Chromosomal Location of Human Ortholog: 17q21.1

Cellular Component: cytoplasm; focal adhesion; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; PDZ domain binding; protein binding; Wnt receptor activity; Wnt-protein binding

Biological Process: cell-cell signaling; epithelial cell differentiation; G-protein coupled receptor protein signaling pathway; hard palate development; inner ear receptor cell development; neuron differentiation; positive regulation of cGMP metabolic process; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; sensory perception of smell; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, calcium modulating pathway; Wnt receptor signaling pathway, planar cell polarity pathway
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 Research Articles on FZD2    1. CD82 enhanced the expression of miR-203 and directly downregulated FZD2 expression, suppressing cancer metastasis/cell migration by inhibiting the Wnt signaling pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FZD2 peptidePathways associated with FZD2 peptide
 Reference Product  PubMed Publications
 WNT5A peptide  >53 publications with FZD2 and WNT5A
 WNT3A peptide  >18 publications with FZD2 and WNT3A
 WNT5B peptide  >15 publications with FZD2 and WNT5B
 LRP6 peptide  >14 publications with FZD2 and LRP6
 LRP5 peptide  >13 publications with FZD2 and LRP5
 WNT1 peptide  >12 publications with FZD2 and WNT1
 ROR2 peptide  >12 publications with FZD2 and ROR2
 DVL2 peptide  >6 publications with FZD2 and DVL2
 DVL3 peptide  >4 publications with FZD2 and DVL3
 DVL1 peptide  >2 publications with FZD2 and DVL1
 Products by Pathway  Pathway Diagram
 Asymmetric Localization Of PCP Proteins Pathway antibodies  Asymmetric Localization Of PCP Proteins Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Beta-catenin Independent WNT Signaling Pathway antibodies  Beta-catenin Independent WNT Signaling Pathway Diagram
 Ca2+ Pathway antibodies  Ca2+ Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Disassembly Of The Destruction Complex And Recruitment Of AXIN To The Membrane Pathway antibodies  Disassembly Of The Destruction Complex And Recruitment Of AXIN To The Membrane Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
Diseases associated with FZD2 peptideOrgans/Tissues associated with FZD2 peptide
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with FZD2 and Inflammation
 Nervous System Diseases Antibodies  >6 publications with FZD2 and Nervous System Diseases
 Brain Diseases Antibodies  >4 publications with FZD2 and Brain Diseases
 Lung Neoplasms Antibodies  >3 publications with FZD2 and Lung Neoplasms
 Fibrosis Antibodies  >3 publications with FZD2 and Fibrosis
 Hyperplasia Antibodies  >3 publications with FZD2 and Hyperplasia
 Myocardial Infarction Antibodies  >3 publications with FZD2 and Myocardial Infarction
 Liver Diseases Antibodies  >2 publications with FZD2 and Liver Diseases
 Breast Neoplasms Antibodies  >2 publications with FZD2 and Breast Neoplasms
 Kidney Diseases Antibodies  >2 publications with FZD2 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with FZD2 and Brain
 Lung Antibodies  >15 publications with FZD2 and Lung
 Embryonic Tissue Antibodies  >13 publications with FZD2 and Embryonic Tissue
 Bone Antibodies  >11 publications with FZD2 and Bone
 Kidney Antibodies  >10 publications with FZD2 and Kidney
 Blood Antibodies  >8 publications with FZD2 and Blood
 Eye Antibodies  >8 publications with FZD2 and Eye
 Uterus Antibodies  >7 publications with FZD2 and Uterus
 Ovary Antibodies  >6 publications with FZD2 and Ovary
 Liver Antibodies  >5 publications with FZD2 and Liver
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