NP_005272.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
G-protein coupled receptor 3
NCBI Official Synonym Full Names
G protein-coupled receptor 3
NCBI Official Synonym Symbols
NCBI Protein Information
G-protein coupled receptor 3; ACCA orphan receptor; adenylate cyclase constitutive activator
UniProt Protein Name
G-protein coupled receptor 3
UniProt Synonym Protein Names
ACCA orphan receptor
UniProt Synonym Gene Names
UniProt Entry Name
GPR3_HUMAN
NCBI Summary for GPR3
This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]
UniProt Comments for GPR3
Function: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress
By similarity, amyloid-beta peptide generation in neurons and neurite outgrowth
By similarity. Maintains also meiotic arrest in oocytes
By similarity. Ref.9 Ref.11
Subcellular location: Cell membrane; Multi-pass membrane protein.
Tissue specificity: Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye. Highly expressed in regions of the brain implicated in the Alzheimer disease.
Induction: Overexpression stimulates amyloid-beta production.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Caution: Was originally (Ref.9) thought to be a receptor for sphingosine 1-phosphate. Ref.10 demonstrated that it is not the case.
Research Articles on GPR3
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with GPR3 peptide
Pathways associated with GPR3 peptide
Diseases associated with GPR3 peptide
Organs/Tissues associated with GPR3 peptide
|