NP_795713.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
P2Y purinoceptor 13
NCBI Official Synonym Full Names
purinergic receptor P2Y, G-protein coupled, 13
NCBI Official Synonym Symbols
GPCR1; GPR86; GPR94; P2Y13; SP174; FKSG77 [Similar Products]
NCBI Protein Information
P2Y purinoceptor 13; G protein-coupled receptor 86; G-protein coupled receptor 86; G-protein coupled receptor 94
UniProt Protein Name
P2Y purinoceptor 13
UniProt Synonym Protein Names
G-protein coupled receptor 86; G-protein coupled receptor 94
UniProt Synonym Gene Names
UniProt Entry Name
P2Y13_HUMAN
NCBI Summary for P2RY13
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. [provided by RefSeq, Sep 2008]
UniProt Comments for P2RY13
Function: Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system. Ref.2
Subcellular location: Cell membrane; Multi-pass membrane protein.
Tissue specificity: Strong expression in spleen and adult brain. Lower expression in placenta, lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, and adrenal gland. Not detected in pancreas, heart, kidney, skeletal muscle, ovary or fetal aorta. Clearly detected in lymph node and bone marrow, weakly detected in peripheral blood mononuclear cells (PBMC) and in peripheral blood leukocytes (PBL), but not detected in polymorphonuclear cells (PMN). In the brain, detected in all brain regions examined.
Miscellaneous: Stimulation by ADP in stably transfected CHO cells resulted in inhibition of adenylyl cyclase and the phosphorylation of the MAP kinases MAPK3 and MAPK1 in a pertussis toxin-sensitive way. Inhibition of adenylyl cyclase and phosphorylation of the MAP kinases are transduction mechanisms that involve G(i) proteins.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Sequence caution: The sequence AAH29363.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.The sequence AAH41116.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAG36024.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
Research Articles on P2RY13
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with P2RY13 peptide
Pathways associated with P2RY13 peptide
Diseases associated with P2RY13 peptide
Organs/Tissues associated with P2RY13 peptide
|