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GCKR peptide

Scan QR to view Datasheet Catalog #    MBS426333 GCKR peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GCKR, Peptide

 Also Known As   

GCKR Immunizing Peptide

 Product Synonym Names    GCKR; glucokinase (hexokinase 4) regulator; GKRP; glucokinase (hexokinase 4) regulatory protein; glucokinase regulator; glucokinase regulatory protein; hexokinase 4
 Product Gene Name   

GCKR peptide

[Similar Products]
 Antibody/Peptide Pairs    GCKR peptide (MBS426333) is used for blocking the activity of GCKR antibody (MBS422063)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    KRFQHVIETP EPGK -C
 OMIM    600842
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 Species Reactivity    Human, Mouse, Rat
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of GCKR peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for GCKR. It may not necessarily be applicable to this product.
 NCBI GI #    4557621
 NCBI GeneID    2646
 NCBI Accession #    NP_001477.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001486.2 [Other Products]
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 UniProt Secondary Accession #    Q53RY6; Q99522; A1L4C2; B4DPQ2 [Other Products]
 UniProt Related Accession #    Q14397 [Other Products]
 Molecular Weight    16,477 Da
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 NCBI Official Full Name    glucokinase regulatory protein
 NCBI Official Synonym Full Names    glucokinase (hexokinase 4) regulator
 NCBI Official Symbol    GCKR [Similar Products]
 NCBI Official Synonym Symbols   
GKRP; FGQTL5
[Similar Products]
 NCBI Protein Information    glucokinase regulatory protein
 UniProt Protein Name    Glucokinase regulatory protein
 Protein Family    Glucokinase regulatory protein
 UniProt Gene Name    GCKR [Similar Products]
 UniProt Synonym Gene Names    GKRP; Glucokinase regulator [Similar Products]
 UniProt Entry Name    GCKR_HUMAN
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 NCBI Summary for GCKR    This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008]
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 UniProt Comments for GCKR    GCKR: a key regulator of glucokinase in the liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen. When expressed alone, both glucokinase and GCKR localize predominantly to the cytoplasm. Co-expression induces both proteins to localize in the nucleus.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 2p23

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: carbohydrate binding; protein binding

Biological Process: carbohydrate metabolic process; negative regulation of glucokinase activity; protein import into nucleus, translocation; response to fructose stimulus; urate metabolic process

Disease: Fasting Plasma Glucose Level Quantitative Trait Locus 5
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 Research Articles on GCKR    1. SNPs in SORT1, CETP and GCKR were individually associated with lipid level variations in Algerian population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GCKR peptidePathways associated with GCKR peptide
 Reference Product  PubMed Publications
 GCK peptide  >45 publications with GCKR and GCK
 Products by Pathway  Pathway Diagram
 Defective TRP May Confer Susceptibility Towards Thyroid Papillary Carcinoma (TPC) Pathway antibodies  Defective TRP May Confer Susceptibility Towards Thyroid Papillary Carcinoma (TPC) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Disorders Of Transmembrane Transporters Pathway antibodies  Disorders Of Transmembrane Transporters Pathway Diagram
 Glucose Transport Pathway antibodies  Glucose Transport Pathway Diagram
 Hexose Transport Pathway antibodies  Hexose Transport Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
 Regulation Of Glucokinase By Glucokinase Regulatory Protein Pathway antibodies  Regulation Of Glucokinase By Glucokinase Regulatory Protein Pathway Diagram
 SLC Transporter Disorders Pathway antibodies  SLC Transporter Disorders Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
Diseases associated with GCKR peptideOrgans/Tissues associated with GCKR peptide
 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 2 Antibodies  >68 publications with GCKR and Diabetes Mellitus, Type 2
 Cardiovascular Diseases Antibodies  >41 publications with GCKR and Cardiovascular Diseases
 Insulin Resistance Antibodies  >38 publications with GCKR and Insulin Resistance
 Liver Diseases Antibodies  >35 publications with GCKR and Liver Diseases
 Fatty Liver Antibodies  >33 publications with GCKR and Fatty Liver
 Hyperglycemia Antibodies  >22 publications with GCKR and Hyperglycemia
 Dyslipidemias Antibodies  >21 publications with GCKR and Dyslipidemias
 Heart Diseases Antibodies  >21 publications with GCKR and Heart Diseases
 Inflammation Antibodies  >19 publications with GCKR and Inflammation
 Hypertriglyceridemia Antibodies  >17 publications with GCKR and Hypertriglyceridemia
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >90 publications with GCKR and Liver
 Vascular Antibodies  >10 publications with GCKR and Vascular
 Lung Antibodies  >7 publications with GCKR and Lung
 Muscle Antibodies  >3 publications with GCKR and Muscle
 Testis Antibodies  >1 publications with GCKR and Testis
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