NP_002063.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,142 Da
NCBI Official Full Name
guanine nucleotide-binding protein G(q) subunit alpha
NCBI Official Synonym Full Names
G protein subunit alpha q
NCBI Protein Information
guanine nucleotide-binding protein G(q) subunit alpha
UniProt Protein Name
Guanine nucleotide-binding protein G(q) subunit alpha
UniProt Synonym Protein Names
Guanine nucleotide-binding protein alpha-q
UniProt Synonym Gene Names
UniProt Entry Name
GNAQ_HUMAN
NCBI Summary for GNAQ
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010]
UniProt Comments for GNAQ
G-alpha(q): a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Protein type: G protein; G protein, heterotrimeric alpha G(q); G protein, heterotrimeric
Chromosomal Location of Human Ortholog: 9q21
Cellular Component: cytoplasm; dendrite; lysosomal membrane; nuclear membrane; photoreceptor outer segment; plasma membrane
Molecular Function: G-protein beta/gamma-subunit binding; GTP binding; GTPase activator activity; GTPase activity; metal ion binding; protein binding; signal transducer activity; type 2A serotonin receptor binding
Biological Process: acetylcholine receptor signaling, muscarinic pathway; blood coagulation; dopamine receptor, phospholipase C activating pathway; embryonic digit morphogenesis; entrainment of circadian clock; forebrain neuron development; G-protein signaling, adenylate cyclase activating pathway; glutamate signaling pathway; heart development; maternal behavior; metabolic process; negative regulation of protein kinase activity; neuron remodeling; phospholipase C activation; phototransduction, visible light; pigmentation during development; platelet activation; positive regulation of GTPase activity; post-embryonic development; protein stabilization; regulation of action potential; regulation of melanocyte differentiation; skeletal development
Disease: Capillary Malformations, Congenital; Sturge-weber Syndrome
Research Articles on GNAQ
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Products associated with GNAQ blocking peptide
Pathways associated with GNAQ blocking peptide
Diseases associated with GNAQ blocking peptide
Organs/Tissues associated with GNAQ blocking peptide
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