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GNAS peptide

Scan QR to view Datasheet Catalog #    MBS427301 GNAS peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GNAS, Peptide

 Also Known As   

GNAS Immunizing Peptide

 Product Synonym Names    GNAS; GNAS complex locus; AHO; C20orf45; GNAS1; GPSA; GSA; GSP; MGC33735; NESP; PHP1A; PHP1B; POH; dJ309F20.1.1; dJ806M20.3.3; OTTHUMP00000031742; OTTHUMP00000196026; OTTHUMP00000196030; adenylate cyclase-stimulating G alpha protein; guanine nucleotide bi
 Product Gene Name   

GNAS peptide

[Similar Products]
 Antibody/Peptide Pairs    GNAS peptide (MBS427301) is used for blocking the activity of GNAS antibody (MBS422378)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-QAARSNSD GEKATK
 OMIM    102200
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 Species Reactivity    Human, Mouse, Rat, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of GNAS peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for GNAS. It may not necessarily be applicable to this product.
 NCBI GI #    4504047
 NCBI GeneID    2778
 NCBI Accession #    NP_000507.1 [Other Products]
 NCBI Related Accession #    NP_001070956.1; NP_001070957.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000516.5 [Other Products]
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 UniProt Secondary Accession #    P04895; Q12927; Q14433; Q32P26; Q5JWD2; Q5JWD4; Q5JWD5; Q6NR75; Q6NXS0; A6NI00; E1P5G5 [Other Products]
 UniProt Related Accession #    P63092; O95467; P84996; Q5JWF2 [Other Products]
 Molecular Weight    111,025 Da
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 NCBI Official Full Name    protein GNAS isoform GNASL
 NCBI Official Synonym Full Names    GNAS complex locus
 NCBI Official Symbol    GNAS [Similar Products]
 NCBI Official Synonym Symbols   
AHO; GSA; GSP; POH; GPSA; NESP; SCG6; SgVI; GNAS1; C20orf45
[Similar Products]
 NCBI Protein Information    protein ALEX; protein GNAS; protein SCG6 (secretogranin VI)
 UniProt Protein Name    Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
 UniProt Synonym Protein Names   
Adenylate cyclase-stimulating G alpha protein
 Protein Family    Protein
 UniProt Gene Name    GNAS [Similar Products]
 UniProt Synonym Gene Names    GNAS1; GSP [Similar Products]
 UniProt Entry Name    GNAS2_HUMAN
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 NCBI Summary for GNAS    This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
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 UniProt Comments for GNAS    G-alpha(s): a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(s); Membrane protein, peripheral; Oncoprotein; Vesicle

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: cytosol; membrane

Molecular Function: beta-2 adrenergic receptor binding; corticotropin-releasing hormone receptor 1 binding; D1 dopamine receptor binding; insulin-like growth factor receptor binding; ionotropic glutamate receptor binding; mu-type opioid receptor binding; protein binding

Biological Process: cognition; developmental growth; dopamine receptor, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase activating pathway; sensory perception of chemical stimulus

Disease: Acth-independent Macronodular Adrenal Hyperplasia; Mccune-albright Syndrome; Osseous Heteroplasia, Progressive; Pituitary Adenoma, Growth Hormone-secreting; Pseudohypoparathyroidism, Type Ia; Pseudohypoparathyroidism, Type Ib; Pseudohypoparathyroidism, Type Ic; Pseudopseudohypoparathyroidism
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 Research Articles on GNAS    1. paternal duplication of the chromosomal region comprising the GNAS locus appears to be a fairly common cause of sporadic Pseudohypoparathyroidism type Ib that is likely to occur with equal frequency in Caucasians and Asians.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GNAS peptidePathways associated with GNAS peptide
 Reference Product  PubMed Publications
 TSHR peptide  >18 publications with GNAS and TSHR
 ADRB2 peptide  >8 publications with GNAS and ADRB2
 LHCGR peptide  >2 publications with GNAS and LHCGR
 ADCY5 peptide  >1 publications with GNAS and ADCY5
 GNB1 peptide  >1 publications with GNAS and GNB1
 GHRHR peptide  >1 publications with GNAS and GHRHR
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
Diseases associated with GNAS peptideOrgans/Tissues associated with GNAS peptide
 Disease Name  Pubmed Publications
 Albright's hereditary osteodystrophy Antibodies  >209 publications with GNAS and Albright's hereditary osteodystrophy
 Pseudopseudohypoparathyroidism Antibodies  >204 publications with GNAS and Pseudopseudohypoparathyroidism
 PSEUDOHYPOPARATHYROIDISM, TYPE IA Antibodies  >204 publications with GNAS and PSEUDOHYPOPARATHYROIDISM, TYPE IA
 Pseudohypoparathyroidism Antibodies  >204 publications with GNAS and Pseudohypoparathyroidism
 Endocrine System Diseases Antibodies  >180 publications with GNAS and Endocrine System Diseases
 Fibrous Dysplasia, Polyostotic Antibodies  >112 publications with GNAS and Fibrous Dysplasia, Polyostotic
 Obesity Antibodies  >67 publications with GNAS and Obesity
 Kidney Diseases Antibodies  >35 publications with GNAS and Kidney Diseases
 Ossification, Heterotopic Antibodies  >33 publications with GNAS and Ossification, Heterotopic
 Pseudohypoparathyroidism Type 1B Antibodies  >30 publications with GNAS and Pseudohypoparathyroidism Type 1B
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >165 publications with GNAS and Bone
 Blood Antibodies  >144 publications with GNAS and Blood
 Parathyroid Antibodies  >103 publications with GNAS and Parathyroid
 Skin Antibodies  >65 publications with GNAS and Skin
 Thyroid Antibodies  >63 publications with GNAS and Thyroid
 Nerve Antibodies  >57 publications with GNAS and Nerve
 Kidney Antibodies  >56 publications with GNAS and Kidney
 Brain Antibodies  >55 publications with GNAS and Brain
 Pancreas Antibodies  >52 publications with GNAS and Pancreas
 Muscle Antibodies  >35 publications with GNAS and Muscle
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