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GCG peptide :: Glucagon Peptide

Scan QR to view Datasheet Catalog #    MBS8246520 GCG peptide
Unit / Price
1 mg  /  $430 +1 FREE 8GB USB
5 mg  /  $990 +1 FREE 8GB USB
10 mg  /  $1,445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glucagon (GCG), Peptide

 Also Known As   

Glucagon (1-37) (Porcine)

 Product Gene Name   

GCG peptide

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    His-Ser-Gl n-Gly-Thr- Phe-Thr-Se r-Asp-Tyr- Ser-Lys-Ty r-Leu-Asp- Ser-Arg-Ar g-Ala-Gln- Asp-Phe-Va l-Gln-Trp- Leu-Met-As n-Thr-Lys- Arg-Asn-Ly s-Asn-Asn- Ile-Ala
 OMIM    138030
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 Host    Synthetic
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 Purity/Purification    > 95%
 Form/Format    Lyophilized powder
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 CAS Number    62340-29-8
 Molecular Formula    C192H295N59O60S
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Other Notes    Small volumes of GCG peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GCG peptide

   Peptide to Glucagon (1-37) (Porcine)
NCBI/Uniprot data below describe general gene information for GCG. It may not necessarily be applicable to this product.
 NCBI GI #    4503945
 NCBI GeneID    2641
 NCBI Accession #    NP_002045.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002054.4 [Other Products]
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 UniProt Secondary Accession #    Q53TP6; A6NN65 [Other Products]
 UniProt Related Accession #    P01275 [Other Products]
 Molecular Weight    4421.92 [Similar Products]
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 NCBI Official Full Name    glucagon preproprotein
 NCBI Official Synonym Full Names    glucagon
 NCBI Official Symbol    GCG [Similar Products]
 NCBI Official Synonym Symbols   
GLP1; GLP2; GRPP
[Similar Products]
 NCBI Protein Information    glucagon
 UniProt Protein Name    Glucagon
 UniProt Synonym Protein Names   
GlicentinGlicentin-related polypeptide; GRPP
 Protein Family    Glucagon
 UniProt Gene Name    GCG [Similar Products]
 UniProt Synonym Gene Names    GRPP; OXM; OXY; GLP-1; GLP-1(7-37); GLP-1(7-36); GLP-2 [Similar Products]
 UniProt Entry Name    GLUC_HUMAN
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 NCBI Summary for GCG    The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GCG    GCG: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. GLP-1 and GLP-2 are induced in response to nutrient ingestion. Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain. Belongs to the glucagon family.

Protein type: Hormone; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q36-q37

Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space; plasma membrane

Molecular Function: glucagon receptor binding; hormone activity; identical protein binding; protein binding; receptor binding

Biological Process: cell proliferation; feeding behavior; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of apoptosis; negative regulation of appetite; positive regulation of cAMP biosynthetic process; positive regulation of histone H3-K4 methylation; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of protein kinase activity; regulation of insulin secretion; response to starvation; signal transduction
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 Research Articles on GCG    1. Data show that NCI-H716 cells were immunostained for tumor necrosis factor receptor TNFR1, and TNFalpha treatment enhances glucagon-like peptide-1 (GLP-1) secretion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GCG peptidePathways associated with GCG peptide
 Reference Product  PubMed Publications
 INS peptide  >19 publications with GCG and INS
 GIP peptide  >18 publications with GCG and GIP
 GLP1R peptide  >12 publications with GCG and GLP1R
 TCF7L2 peptide  >8 publications with GCG and TCF7L2
 GCGR peptide  >7 publications with GCG and GCGR
 GLP2R peptide  >4 publications with GCG and GLP2R
 PAX6 peptide  >4 publications with GCG and PAX6
 FOXA2 peptide  >3 publications with GCG and FOXA2
 CDX2 peptide  >2 publications with GCG and CDX2
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Glucagon Signaling In Metabolic Regulation Pathway antibodies  Glucagon Signaling In Metabolic Regulation Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
Diseases associated with GCG peptideOrgans/Tissues associated with GCG peptide
 Disease Name  Pubmed Publications
 Muscular Diseases Antibodies  >73 publications with GCG and Muscular Diseases
 Diabetes Mellitus, Type 2 Antibodies  >28 publications with GCG and Diabetes Mellitus, Type 2
 Obesity Antibodies  >22 publications with GCG and Obesity
 Vascular Diseases Antibodies  >15 publications with GCG and Vascular Diseases
 Hyperglycemia Antibodies  >13 publications with GCG and Hyperglycemia
 Insulin Resistance Antibodies  >13 publications with GCG and Insulin Resistance
 Kidney Diseases Antibodies  >12 publications with GCG and Kidney Diseases
 Liver Diseases Antibodies  >10 publications with GCG and Liver Diseases
 Hyperinsulinism Antibodies  >10 publications with GCG and Hyperinsulinism
 Pain Antibodies  >9 publications with GCG and Pain
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >49 publications with GCG and Pancreas
 Liver Antibodies  >23 publications with GCG and Liver
 Intestine Antibodies  >21 publications with GCG and Intestine
 Connective Tissue Antibodies  >14 publications with GCG and Connective Tissue
 Stomach Antibodies  >7 publications with GCG and Stomach
 Embryonic Tissue Antibodies  >6 publications with GCG and Embryonic Tissue
 Uterus Antibodies  >1 publications with GCG and Uterus
 Uncharacterized Tissue Antibodies  >1 publications with GCG and Uncharacterized Tissue
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