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HMGCR peptide :: HMGCR / LDLCQ3 Peptide

Scan QR to view Datasheet Catalog #    MBS425433 HMGCR peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HMGCR / LDLCQ3, Peptide

★Popular Item★
 Also Known As   

HMGCR / LDLCQ3 Immunizing Peptide

 Product Synonym Names    HMGCR; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; LDLCQ3; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); hydroxymethylglutaryl-CoA reductase; HMG-CoA reductase; HMGCR / LDLCQ3
 Product Gene Name   

HMGCR peptide

[Similar Products]
 Product Synonym Gene Name    LDLCQ3 [Similar Products]
 Antibody/Peptide Pairs    HMGCR / LDLCQ3 peptide (MBS425433) is used for blocking the activity of HMGCR/LDLCQ3 antibody (MBS422211)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-ADPSPQNS TADTSK
 OMIM    142910
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 Form/Format    100ug of dried peptide
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 Use    The peptide was used in the production of MBS422211 Goat Anti-HMGCR / LDLCQ3 Antibody. It is currently untested in blocking applications.
 Supplied As    100ug of Lyophilised peptide, formulation 5pmol/uL in 5% (v/v) acetonitrile/H2O. Reconstitute pellet in distilled water where required. For Blocking studies, reconstitute pellet in 200ul distilled water to obtain a 0.5mg/ml peptide solution.
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of HMGCR peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for HMGCR. It may not necessarily be applicable to this product.
 NCBI GI #    4557643
 NCBI GeneID    3156
 NCBI Accession #    NP_000850.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000859.2 [Other Products]
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 UniProt Secondary Accession #    Q8N190; B7Z3Y9 [Other Products]
 UniProt Related Accession #    P04035 [Other Products]
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 NCBI Official Full Name    3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 1
 NCBI Official Synonym Full Names    3-hydroxy-3-methylglutaryl-CoA reductase
 NCBI Official Symbol    HMGCR [Similar Products]
 NCBI Official Synonym Symbols   
LDLCQ3
[Similar Products]
 NCBI Protein Information    3-hydroxy-3-methylglutaryl-Coenzyme A reductase
 UniProt Protein Name    3-hydroxy-3-methylglutaryl-coenzyme A reductase
 UniProt Gene Name    HMGCR [Similar Products]
 UniProt Synonym Gene Names    HMG-CoA reductase [Similar Products]
 UniProt Entry Name    HMDH_HUMAN
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 NCBI Summary for HMGCR    HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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 UniProt Comments for HMGCR    HMGCR: the rate-limiting enzyme for cholesterol synthesis. Regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by this reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.

Protein type: Endoplasmic reticulum; Membrane protein, integral; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Motility/polarity/chemotaxis; Oxidoreductase; Membrane protein, multi-pass; EC 1.1.1.34

Chromosomal Location of Human Ortholog: 5q13.3-q14

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; peroxisomal membrane

Molecular Function: coenzyme binding; hydroxymethylglutaryl-CoA reductase (NADPH) activity; hydroxymethylglutaryl-CoA reductase activity; protein binding; protein homodimerization activity; protein phosphatase 2A binding

Biological Process: aging; cholesterol biosynthetic process; coenzyme A metabolic process; isoprenoid biosynthetic process; myoblast differentiation; negative regulation of MAP kinase activity; negative regulation of vasodilation; positive regulation of skeletal muscle development; positive regulation of smooth muscle cell proliferation; positive regulation of stress-activated MAPK cascade; protein tetramerization; response to ethanol; response to nutrient; ubiquinone metabolic process; visual learning
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 Research Articles on HMGCR    1. the results of the present study showed that luteolin modulates HMGCR transcription by decreasing the expression and nuclear translocation of SREBP-2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HMGCR peptidePathways associated with HMGCR peptide
 Reference Product  PubMed Publications
 SREBF2 peptide  >39 publications with HMGCR and SREBF2
 HMGCS1 peptide  >24 publications with HMGCR and HMGCS1
 INSIG1 peptide  >7 publications with HMGCR and INSIG1
 MVK peptide  >4 publications with HMGCR and MVK
 PPARA peptide  >2 publications with HMGCR and PPARA
 HMGCS2 peptide  >2 publications with HMGCR and HMGCS2
 UBIAD1 peptide  >1 publications with HMGCR and UBIAD1
 UBC peptide  >1 publications with HMGCR and UBC
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
Diseases associated with HMGCR peptideOrgans/Tissues associated with HMGCR peptide
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >79 publications with HMGCR and Cardiovascular Diseases
 Fatty Liver Antibodies  >66 publications with HMGCR and Fatty Liver
 Dyslipidemias Antibodies  >53 publications with HMGCR and Dyslipidemias
 Atherosclerosis Antibodies  >52 publications with HMGCR and Atherosclerosis
 Hypercholesterolemia Antibodies  >51 publications with HMGCR and Hypercholesterolemia
 Liver Diseases Antibodies  >49 publications with HMGCR and Liver Diseases
 Hyperlipidemias Antibodies  >44 publications with HMGCR and Hyperlipidemias
 Necrosis Antibodies  >38 publications with HMGCR and Necrosis
 Inflammation Antibodies  >37 publications with HMGCR and Inflammation
 Muscular Diseases Antibodies  >35 publications with HMGCR and Muscular Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >210 publications with HMGCR and Liver
 Blood Antibodies  >194 publications with HMGCR and Blood
 Muscle Antibodies  >61 publications with HMGCR and Muscle
 Brain Antibodies  >43 publications with HMGCR and Brain
 Heart Antibodies  >40 publications with HMGCR and Heart
 Vascular Antibodies  >27 publications with HMGCR and Vascular
 Kidney Antibodies  >27 publications with HMGCR and Kidney
 Ovary Antibodies  >17 publications with HMGCR and Ovary
 Connective Tissue Antibodies  >15 publications with HMGCR and Connective Tissue
 Nerve Antibodies  >14 publications with HMGCR and Nerve
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