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HSPA8 peptide

Scan QR to view Datasheet Catalog #    MBS425020 HSPA8 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HSPA8, Peptide

 Also Known As   

HSPA8 Immunizing Peptide

 Product Synonym Names    HSPA8; heat shock 70kDa protein 8; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; LAP; MGC131511; MGC29929; NIP71; LPS-associated protein 1; N-myristoyltransferase inhibitor protein 71; constitutive heat shock protein 70; heat shock 70kD protein 8; heat sh; HSPA8 (Isoform 1)
 Product Gene Name   

HSPA8 peptide

[Similar Products]
 Antibody/Peptide Pairs    HSPA8 peptide (MBS425020) is used for blocking the activity of HSPA8 antibody (MBS420451)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-EKLQGKIN DEDKQK
 OMIM    600816
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 Species Reactivity    Human, Mouse, Rat, Dog
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of HSPA8 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for HSPA8. It may not necessarily be applicable to this product.
 NCBI GI #    5729877
 NCBI GeneID    3312
 NCBI Accession #    NP_006588.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006597.5 [Other Products]
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 UniProt Secondary Accession #    Q9H3R6 [Other Products]
 UniProt Related Accession #    P11142 [Other Products]
 Molecular Weight    53,518 Da
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 NCBI Official Full Name    heat shock cognate 71 kDa protein isoform 1
 NCBI Official Synonym Full Names    heat shock protein family A (Hsp70) member 8
 NCBI Official Symbol    HSPA8 [Similar Products]
 NCBI Official Synonym Symbols   
LAP1; HSC54; HSC70; HSC71; HSP71; HSP73; LAP-1; NIP71; HEL-33; HSPA10; HEL-S-72p
[Similar Products]
 NCBI Protein Information    heat shock cognate 71 kDa protein
 UniProt Protein Name    Heat shock cognate 71 kDa protein
 UniProt Synonym Protein Names   
Heat shock 70 kDa protein 8; Lipopolysaccharide-associated protein 1; LAP-1; LPS-associated protein 1
 UniProt Gene Name    HSPA8 [Similar Products]
 UniProt Synonym Gene Names    HSC70; HSP73; HSPA10; LAP-1; LPS-associated protein 1 [Similar Products]
 UniProt Entry Name    HSP7C_HUMAN
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 NCBI Summary for HSPA8    This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
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 UniProt Comments for HSPA8    HSC70: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co- chaperones. Interacts with HSPH1/HSP105. Interacts with IRAK1BP1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG and TSC2. Interacts with BAG1. Interacts with SV40 VP1. Interacts with DNAJC7. Interacts with HERC5. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation. Constitutively synthesized. Ubiquitous. Belongs to the heat shock protein 70 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Chaperone; RNA-binding; Heat shock protein; Nucleolus

Chromosomal Location of Human Ortholog: 11q24.1

Cellular Component: cytosol; extracellular space; focal adhesion; intracellular; late endosome; lysosomal lumen; lysosomal membrane; melanosome; membrane; myelin sheath; nucleolus; nucleoplasm; nucleus; plasma membrane; ribonucleoprotein complex; spliceosome; ubiquitin ligase complex

Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled; enzyme binding; G-protein-coupled receptor binding; heat shock protein binding; phosphatidylserine binding; protein binding; ubiquitin protein ligase binding; unfolded protein binding

Biological Process: ATP metabolic process; cellular response to starvation; chaperone cofactor-dependent protein folding; negative regulation of transcription, DNA-dependent; neurotransmitter secretion; nuclear mRNA splicing, via spliceosome; positive regulation of nuclear mRNA splicing, via spliceosome; protein folding; protein refolding; protein targeting to lysosome; regulation of cell cycle; regulation of mRNA stability; regulation of protein complex assembly; regulation of protein stability; response to unfolded protein; transcription, DNA-dependent; viral reproduction
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 Research Articles on HSPA8    1. Active Hsc70 requires active tau to regulate microtubule assembly in vivo, suggesting that tau acts in some ways as a co-chaperone for Hsc70 to coordinate microtubule assembly.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HSPA8 peptidePathways associated with HSPA8 peptide
 Reference Product  PubMed Publications
 STUB1 peptide  >27 publications with HSPA8 and STUB1
 DNAJB1 peptide  >24 publications with HSPA8 and DNAJB1
 CFTR peptide  >15 publications with HSPA8 and CFTR
 DNAJA1 peptide  >11 publications with HSPA8 and DNAJA1
 HSP90AA1 peptide  >8 publications with HSPA8 and HSP90AA1
 BAG1 peptide  >6 publications with HSPA8 and BAG1
 BAG2 peptide  >2 publications with HSPA8 and BAG2
 DNAJB6 peptide  >2 publications with HSPA8 and DNAJB6
 Products by Pathway  Pathway Diagram
 AUF1 (hnRNP D0) Binds And Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Binds And Destabilizes MRNA Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Attenuation Phase Pathway antibodies  Attenuation Phase Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 CHL1 Interactions Pathway antibodies  CHL1 Interactions Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
Diseases associated with HSPA8 peptideOrgans/Tissues associated with HSPA8 peptide
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >62 publications with HSPA8 and Nervous System Diseases
 Brain Diseases Antibodies  >47 publications with HSPA8 and Brain Diseases
 Cardiovascular Diseases Antibodies  >30 publications with HSPA8 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >26 publications with HSPA8 and Disease Models, Animal
 Heart Diseases Antibodies  >19 publications with HSPA8 and Heart Diseases
 Inflammation Antibodies  >17 publications with HSPA8 and Inflammation
 Necrosis Antibodies  >17 publications with HSPA8 and Necrosis
 Fibrosis Antibodies  >17 publications with HSPA8 and Fibrosis
 Liver Diseases Antibodies  >14 publications with HSPA8 and Liver Diseases
 Adenocarcinoma Antibodies  >12 publications with HSPA8 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >104 publications with HSPA8 and Blood
 Brain Antibodies  >103 publications with HSPA8 and Brain
 Liver Antibodies  >50 publications with HSPA8 and Liver
 Muscle Antibodies  >50 publications with HSPA8 and Muscle
 Nerve Antibodies  >43 publications with HSPA8 and Nerve
 Heart Antibodies  >37 publications with HSPA8 and Heart
 Kidney Antibodies  >31 publications with HSPA8 and Kidney
 Vascular Antibodies  >18 publications with HSPA8 and Vascular
 Lung Antibodies  >16 publications with HSPA8 and Lung
 Bone Antibodies  >12 publications with HSPA8 and Bone
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