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TSC1 peptide :: Hamartin / TSC1 Peptide

Scan QR to view Datasheet Catalog #    MBS426893 TSC1 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hamartin / TSC1, Peptide

 Also Known As   

Hamartin / TSC1 Immunizing Peptide

 Product Synonym Names    TSC1; hamartin; tuberous sclerosis 1; HGNC: 12362; KIAA0243; LAM; MGC86987; TSC; tuberous sclerosis 1 protein; tumor suppressor; Hamartin; Hamartin / TSC1 (isoform 1)
 Product Gene Name   

TSC1 peptide

[Similar Products]
 Antibody/Peptide Pairs    Hamartin / TSC1 peptide (MBS426893) is used for blocking the activity of Hamartin/TSC1 antibody (MBS420710)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-QLHIMDYN ETHHEH
 OMIM    191100
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 Species Reactivity    Human, Mouse, Rat, Dog
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of TSC1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for TSC1. It may not necessarily be applicable to this product.
 NCBI GI #    4507693
 NCBI GeneID    7248
 NCBI Accession #    NP_000359.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000368.4 [Other Products]
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 UniProt Secondary Accession #    Q5VVN5; B7Z897 [Other Products]
 UniProt Related Accession #    Q92574 [Other Products]
 Molecular Weight    124,015 Da
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 NCBI Official Full Name    hamartin isoform 1
 NCBI Official Synonym Full Names    tuberous sclerosis 1
 NCBI Official Symbol    TSC1 [Similar Products]
 NCBI Official Synonym Symbols   
LAM; TSC
[Similar Products]
 NCBI Protein Information    hamartin
 UniProt Protein Name    Hamartin
 UniProt Synonym Protein Names   
Tuberous sclerosis 1 protein
 Protein Family    Hamartin
 UniProt Gene Name    TSC1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0243; TSC [Similar Products]
 UniProt Entry Name    TSC1_HUMAN
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 NCBI Summary for TSC1    This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
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 UniProt Comments for TSC1    TSC1: tuberous sclerosis protein 1 (TSC1). May have tumor suppressor activity. Together with tuberin (TSC2), inhibits mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase. Regulated by the phosphatidylinositol 3-kinase/Akt pathway and phosphorylation of tuberin. Phosphorylated by cyclin-dependent kinase 1/cyclin B during the cell cycle.

Protein type: Tumor suppressor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: actin filament; cell cortex; cytoplasm; cytosol; growth cone; lamellipodium; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; TSC1-TSC2 complex

Molecular Function: chaperone binding; GTPase activating protein binding; GTPase regulator activity; protein binding; protein N-terminus binding

Biological Process: adaptive immune response; adult locomotory behavior; cardiac muscle cell differentiation; cell cycle arrest; cell projection organization and biogenesis; cell-matrix adhesion; cerebral cortex development; glucose import; hippocampus development; kidney development; memory T cell differentiation; myelination; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of insulin receptor signaling pathway; negative regulation of macroautophagy; negative regulation of TOR signaling pathway; negative regulation of translation; neural tube closure; positive regulation of focal adhesion formation; potassium ion transport; protein heterooligomerization; protein stabilization; regulation of cell cycle; regulation of cell-matrix adhesion; regulation of phosphoprotein phosphatase activity; regulation of protein kinase activity; regulation of stress fiber formation; regulation of translation; response to insulin stimulus; rRNA export from nucleus; synapse organization and biogenesis

Disease: Focal Cortical Dysplasia Of Taylor; Lymphangioleiomyomatosis; Tuberous Sclerosis 1
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 Research Articles on TSC1    1. Data show that microRNA miR-451 target tuberous sclerosis 1 (TSC1) gene and activates the PI3-kinase/Akt protein/mTOR protein signaling in multiple myeloma (MM) Side population (SP) cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TSC1 peptidePathways associated with TSC1 peptide
 Reference Product  PubMed Publications
 TSC2 peptide  >1032 publications with TSC1 and TSC2
 MTOR peptide  >623 publications with TSC1 and MTOR
 RHEB peptide  >166 publications with TSC1 and RHEB
 AKT1 peptide  >37 publications with TSC1 and AKT1
 RICTOR peptide  >26 publications with TSC1 and RICTOR
 IKBKB peptide  >9 publications with TSC1 and IKBKB
 RPS6KA1 peptide  >8 publications with TSC1 and RPS6KA1
 CDK1 peptide  >4 publications with TSC1 and CDK1
 AKT3 peptide  >3 publications with TSC1 and AKT3
 AKT2 peptide  >3 publications with TSC1 and AKT2
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
 Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway antibodies  Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 IGF1R Signaling Cascade Pathway antibodies  IGF1R Signaling Cascade Pathway Diagram
Diseases associated with TSC1 peptideOrgans/Tissues associated with TSC1 peptide
 Disease Name  Pubmed Publications
 Tuberous Sclerosis Antibodies  >1110 publications with TSC1 and Tuberous Sclerosis
 Epilepsy Antibodies  >189 publications with TSC1 and Epilepsy
 Brain Diseases Antibodies  >151 publications with TSC1 and Brain Diseases
 Lymphangioleiomyomatosis Antibodies  >108 publications with TSC1 and Lymphangioleiomyomatosis
 Kidney Diseases Antibodies  >106 publications with TSC1 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >47 publications with TSC1 and Cardiovascular Diseases
 Tuberous Sclerosis 1 Antibodies  >46 publications with TSC1 and Tuberous Sclerosis 1
 Carcinoma, Renal Cell Antibodies  >44 publications with TSC1 and Carcinoma, Renal Cell
 Liver Neoplasms Antibodies  >35 publications with TSC1 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >32 publications with TSC1 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >359 publications with TSC1 and Brain
 Kidney Antibodies  >177 publications with TSC1 and Kidney
 Lung Antibodies  >130 publications with TSC1 and Lung
 Blood Antibodies  >119 publications with TSC1 and Blood
 Skin Antibodies  >113 publications with TSC1 and Skin
 Muscle Antibodies  >109 publications with TSC1 and Muscle
 Heart Antibodies  >107 publications with TSC1 and Heart
 Liver Antibodies  >76 publications with TSC1 and Liver
 Vascular Antibodies  >54 publications with TSC1 and Vascular
 Bladder Antibodies  >34 publications with TSC1 and Bladder
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