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MYF6 peptide :: Herculin / MYF6 Peptide

Scan QR to view Datasheet Catalog #    MBS427273 MYF6 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Herculin / MYF6, Peptide

 Also Known As   

Herculin / MYF6 Immunizing Peptide

 Product Synonym Names    MYF6; myogenic factor 6 (herculin); MRF4; bHLHc4; herculin; myogenic factor 6; myogenic factor-6; Herculin; Herculin / MYF6
 Product Gene Name   

MYF6 peptide

[Similar Products]
 Antibody/Peptide Pairs    Herculin / MYF6 peptide (MBS427273) is used for blocking the activity of Herculin/MYF6 antibody (MBS422345)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-SYRPKQEN LEGAD
 OMIM    159991
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 Species Reactivity    Human, Mouse, Rat, Cow, Pig
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of MYF6 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for MYF6. It may not necessarily be applicable to this product.
 NCBI GI #    4505299
 NCBI GeneID    4618
 NCBI Accession #    NP_002460.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002469.2 [Other Products]
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 UniProt Secondary Accession #    Q53X80; Q6FHI9; B2R898 [Other Products]
 UniProt Related Accession #    P23409 [Other Products]
 Molecular Weight    26,953 Da
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 NCBI Official Full Name    myogenic factor 6
 NCBI Official Synonym Full Names    myogenic factor 6
 NCBI Official Symbol    MYF6 [Similar Products]
 NCBI Official Synonym Symbols   
CNM3; MRF4; myf-6; bHLHc4
[Similar Products]
 NCBI Protein Information    myogenic factor 6
 UniProt Protein Name    Myogenic factor 6
 UniProt Synonym Protein Names   
Class C basic helix-loop-helix protein 4; bHLHc4; Muscle-specific regulatory factor 4
 Protein Family    Myogenic factor
 UniProt Gene Name    MYF6 [Similar Products]
 UniProt Synonym Gene Names    BHLHC4; MRF4; Myf-6; bHLHc4 [Similar Products]
 UniProt Entry Name    MYF6_HUMAN
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 NCBI Summary for MYF6    The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM). [provided by RefSeq, May 2010]
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 UniProt Comments for MYF6    Myf-6: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. Defects in MYF6 may be a cause of centronuclear myopathy type 3 (CNM3). A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q21

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein heterodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; transcription factor activity

Biological Process: muscle cell fate commitment; negative regulation of transcription, DNA-dependent; positive regulation of muscle cell differentiation; positive regulation of myoblast differentiation; positive regulation of skeletal muscle fiber development; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; skeletal muscle development; skeletal muscle regeneration; somitogenesis; transcription from RNA polymerase II promoter

Disease: Myopathy, Centronuclear, 3
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 Research Articles on MYF6    1. Observational study of gene-disease association. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MYF6 peptideDiseases associated with MYF6 peptide
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 Myogenesis Pathway antibodies  Myogenesis Pathway Diagram
 Disease Name  Pubmed Publications
 Muscular Dystrophy, Duchenne Antibodies  >3 publications with MYF6 and Muscular Dystrophy, Duchenne
 Fibrosis Antibodies  >2 publications with MYF6 and Fibrosis
 Necrosis Antibodies  >2 publications with MYF6 and Necrosis
 Disease Models, Animal Antibodies  >2 publications with MYF6 and Disease Models, Animal
 MYOPATHY, CENTRONUCLEAR, 1 Antibodies  >2 publications with MYF6 and MYOPATHY, CENTRONUCLEAR, 1
 Weight Loss Antibodies  >1 publications with MYF6 and Weight Loss
 Lung Diseases Antibodies  >1 publications with MYF6 and Lung Diseases
 Inflammation Antibodies  >1 publications with MYF6 and Inflammation
Organs/Tissues associated with MYF6 peptide
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >76 publications with MYF6 and Muscle
 Heart Antibodies  >3 publications with MYF6 and Heart
 Brain Antibodies  >1 publications with MYF6 and Brain
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