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| Product Name
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Histamine Receptor H2 (HRH2), Peptide
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| Also Known As
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Histamine Receptor H2 Immunizing Peptide
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| Product Synonym Names
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HRH2; histamine receptor H2; H2R; HH2R; gastric receptor 1; gastric receptor I; histamine H2 receptor; Histamine Receptor H2; Histamine Receptor H2 (aa309-323)
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| Product Gene Name
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[Similar Products]
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| Antibody/Peptide Pairs
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Histamine Receptor H2 peptide (MBS427414) is used for blocking the activity of Histamine Receptor H2 antibody (MBS422789)
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Sequence
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C-SHNSHKTS LRLNNS
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| OMIM
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142703
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| Species Reactivity
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Human
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| Form/Format
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100ug of dried peptide
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| Preparation and Storage
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Shipped at ambient temperature, store at -20 degree C
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| ISO Certification
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Manufactured in an ISO 9001:2015 Certified Laboratory.
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| Other Notes
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Small volumes of HRH2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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| NCBI/Uniprot data below describe general gene information for HRH2. It may not necessarily be applicable to this product. |
| NCBI GI #
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197085610
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| NCBI GeneID
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3274
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| NCBI Accession #
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NP_001124527.1
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[Other Products]
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| NCBI Related Accession #
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NP_071640.1
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_001131055.1
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[Other Products]
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| UniProt Secondary Accession #
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Q14464; Q7Z5R9; B5BUP7
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[Other Products]
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| UniProt Related Accession #
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P25021
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[Other Products]
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| Molecular Weight
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44,541 Da
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TOP
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| NCBI Official Full Name
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histamine H2 receptor isoform 1
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| NCBI Official Synonym Full Names
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histamine receptor H2
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| NCBI Official Symbol
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HRH2
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[Similar Products]
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| NCBI Official Synonym Symbols
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H2R
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[Similar Products]
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| NCBI Protein Information
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histamine H2 receptor
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| UniProt Protein Name
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Histamine H2 receptor
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| UniProt Synonym Protein Names
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Gastric receptor I
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| Protein Family
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Histamine H2 receptor
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| UniProt Gene Name
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HRH2
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[Similar Products]
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| UniProt Synonym Gene Names
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H2R; HH2R
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[Similar Products]
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| UniProt Entry Name
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HRH2_HUMAN
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| NCBI Summary for HRH2
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Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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| UniProt Comments for HRH2
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H2R: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1
Chromosomal Location of Human Ortholog: 5q35.2
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: histamine receptor activity
Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; gastrin-induced gastric acid secretion; gland development; gut development; histamine-induced gastric acid secretion; immune response; memory; positive regulation of vasoconstriction; regulation of synaptic plasticity; visual learning
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TOP
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| Research Articles on HRH2
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1. Thus, the results in the initial study were due to the degradation of histamine in skeletal muscle by ascorbate, because the histaminergic vasodilatation was unaffected by N-acetylcysteine.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Pathways associated with HRH2 peptide | Diseases associated with HRH2 peptide |
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| Organs/Tissues associated with HRH2 peptide |
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Peptide 
