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HRH2 peptide :: Histamine Receptor H2 Peptide

Scan QR to view Datasheet Catalog #    MBS427414 HRH2 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Histamine Receptor H2 (HRH2), Peptide

 Also Known As   

Histamine Receptor H2 Immunizing Peptide

 Product Synonym Names    HRH2; histamine receptor H2; H2R; HH2R; gastric receptor 1; gastric receptor I; histamine H2 receptor; Histamine Receptor H2; Histamine Receptor H2 (aa309-323)
 Product Gene Name   

HRH2 peptide

[Similar Products]
 Antibody/Peptide Pairs    Histamine Receptor H2 peptide (MBS427414) is used for blocking the activity of Histamine Receptor H2 antibody (MBS422789)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-SHNSHKTS LRLNNS
 OMIM    142703
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 Species Reactivity    Human
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of HRH2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for HRH2. It may not necessarily be applicable to this product.
 NCBI GI #    197085610
 NCBI GeneID    3274
 NCBI Accession #    NP_001124527.1 [Other Products]
 NCBI Related Accession #    NP_071640.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001131055.1 [Other Products]
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 UniProt Secondary Accession #    Q14464; Q7Z5R9; B5BUP7 [Other Products]
 UniProt Related Accession #    P25021 [Other Products]
 Molecular Weight    44,541 Da
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 NCBI Official Full Name    histamine H2 receptor isoform 1
 NCBI Official Synonym Full Names    histamine receptor H2
 NCBI Official Symbol    HRH2 [Similar Products]
 NCBI Official Synonym Symbols   
H2R
[Similar Products]
 NCBI Protein Information    histamine H2 receptor
 UniProt Protein Name    Histamine H2 receptor
 UniProt Synonym Protein Names   
Gastric receptor I
 Protein Family    Histamine H2 receptor
 UniProt Gene Name    HRH2 [Similar Products]
 UniProt Synonym Gene Names    H2R; HH2R [Similar Products]
 UniProt Entry Name    HRH2_HUMAN
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 NCBI Summary for HRH2    Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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 UniProt Comments for HRH2    H2R: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 5q35.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: histamine receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; gastrin-induced gastric acid secretion; gland development; gut development; histamine-induced gastric acid secretion; immune response; memory; positive regulation of vasoconstriction; regulation of synaptic plasticity; visual learning
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 Research Articles on HRH2    1. Thus, the results in the initial study were due to the degradation of histamine in skeletal muscle by ascorbate, because the histaminergic vasodilatation was unaffected by N-acetylcysteine.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with HRH2 peptideDiseases associated with HRH2 peptide
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Disease Name  Pubmed Publications
 Drug Hypersensitivity Antibodies  >3 publications with HRH2 and Drug Hypersensitivity
 Inflammation Antibodies  >3 publications with HRH2 and Inflammation
 Pain Antibodies  >2 publications with HRH2 and Pain
 Urticaria Antibodies  >2 publications with HRH2 and Urticaria
 Seizures Antibodies  >2 publications with HRH2 and Seizures
 Neoplasms, Experimental Antibodies  >2 publications with HRH2 and Neoplasms, Experimental
 Ulcer Antibodies  >1 publications with HRH2 and Ulcer
 Kidney Diseases Antibodies  >1 publications with HRH2 and Kidney Diseases
 Peptic Ulcer Antibodies  >1 publications with HRH2 and Peptic Ulcer
Organs/Tissues associated with HRH2 peptide
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with HRH2 and Brain
 Skin Antibodies  >2 publications with HRH2 and Skin
 Kidney Antibodies  >1 publications with HRH2 and Kidney
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