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DEF6 peptide :: IBP / DEF6 Peptide

Scan QR to view Datasheet Catalog #    MBS425424 DEF6 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IBP / DEF6, Peptide

 Also Known As   

IBP / DEF6 Immunizing Peptide

 Product Synonym Names    DEF6; IBP; differentially expressed in FDCP 6 homolog; RP3-329A5.5; SLAT; IRF4-binding protein; OTTHUMP00000016251; differentially expressed in FDCP 6 homolog (mouse); SWAP70L; SWAP-70-like adaptor protein of T cells; IBP / DEF6
 Product Gene Name   

DEF6 peptide

[Similar Products]
 Product Synonym Gene Name    IBP [Similar Products]
 Antibody/Peptide Pairs    IBP / DEF6 peptide (MBS425424) is used for blocking the activity of IBP/DEF6 antibody (MBS420505)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    610094
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 Species Reactivity    Human, Mouse, Rat, Dog, Pig, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of DEF6 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for DEF6. It may not necessarily be applicable to this product.
 NCBI GI #    145312241
 NCBI GeneID    50619
 NCBI Accession #    NP_071330.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_022047.3 [Other Products]
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 UniProt Secondary Accession #    Q86VF4 [Other Products]
 UniProt Related Accession #    Q9H4E7 [Other Products]
 Molecular Weight    73,910 Da
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 NCBI Official Full Name    differentially expressed in FDCP 6 homolog
 NCBI Official Synonym Full Names    DEF6, guanine nucleotide exchange factor
 NCBI Official Symbol    DEF6 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    differentially expressed in FDCP 6 homolog
 UniProt Protein Name    Differentially expressed in FDCP 6 homolog
 UniProt Synonym Protein Names   
IRF4-binding protein
 Protein Family    Differentially expressed in FDCP
 UniProt Gene Name    DEF6 [Similar Products]
 UniProt Synonym Gene Names    IBP; DEF-6 [Similar Products]
 UniProt Entry Name    DEFI6_HUMAN
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 NCBI Summary for DEF6    DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for DEF6    DEF6: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling.

Protein type: GEFs; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 6p21.33-p21.1

Cellular Component: cytoskeleton; filopodium; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane

Molecular Function: protein binding
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 Research Articles on DEF6    1. IBP was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with DEF6 peptideDiseases associated with DEF6 peptide
 Products by Pathway  Pathway Diagram
 Regulation Of RAC1 Activity Pathway antibodies  Regulation Of RAC1 Activity Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with DEF6 and Inflammation
 Immune System Diseases Antibodies  >7 publications with DEF6 and Immune System Diseases
 Lupus Erythematosus, Systemic Antibodies  >5 publications with DEF6 and Lupus Erythematosus, Systemic
 Disease Models, Animal Antibodies  >4 publications with DEF6 and Disease Models, Animal
 Kidney Diseases Antibodies  >2 publications with DEF6 and Kidney Diseases
 Nervous System Diseases Antibodies  >2 publications with DEF6 and Nervous System Diseases
 Carcinoma, Squamous Cell Antibodies  >1 publications with DEF6 and Carcinoma, Squamous Cell
 Neoplasm Metastasis Antibodies  >1 publications with DEF6 and Neoplasm Metastasis
Organs/Tissues associated with DEF6 peptide
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with DEF6 and Blood
 Lymph Node Antibodies  >2 publications with DEF6 and Lymph Node
 Bone Antibodies  >1 publications with DEF6 and Bone
 Pharynx Antibodies  >1 publications with DEF6 and Pharynx
 Bone Marrow Antibodies  >1 publications with DEF6 and Bone Marrow
 Skin Antibodies  >1 publications with DEF6 and Skin
 Eye Antibodies  >1 publications with DEF6 and Eye
 Tonsil Antibodies  >1 publications with DEF6 and Tonsil
 Mouth Antibodies  >1 publications with DEF6 and Mouth
 Spleen Antibodies  >1 publications with DEF6 and Spleen
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