NP_524551.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Ice
NCBI Official Synonym Symbols
caspase 3; CG7788; crice; DmelCG7788; drice; drIce; drICE; Drice; DrIce; DrICE; DRICE; ice; ICE [Similar Products]
NCBI Protein Information
CG7788 gene product from transcript CG7788-RA; CG7788-PA; Ice; Ice-PA; caspase-3; drice; interleukin-1beta-converting enzyme
UniProt Protein Name
Caspase
UniProt Synonym Protein Names
drICE
UniProt Entry Name
ICE_DROME
UniProt Comments for Ice
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Acts downstream of rpr. Cleaves baculovirus p35 and lamin DmO in vitro.
Subunit structure: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 21 kDa (p21) and a 12 kDa (p12) subunit. Inactive pro-form can homodimerize. Nc and Ice can form a stable complex. Ref.5
Developmental stage: Expressed at all stages where apoptosis occurs.
Sequence similarities: Belongs to the peptidase C14A family.
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Products associated with Ice peptide
Pathways associated with Ice peptide
Diseases associated with Ice peptide
Organs/Tissues associated with Ice peptide
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