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IRF8 peptide :: ICSBP1 / IRF8 Peptide

Scan QR to view Datasheet Catalog #    MBS425759 IRF8 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ICSBP1 / IRF8, Peptide

 Also Known As   

ICSBP1 / IRF8 Immunizing Peptide

 Product Synonym Names    IRF8; ICSBP1; interferon consensus sequence binding protein 1; IRF-8; H-ICSBP; interferon regulatory factor 8; ICSBP1 / IRF8
 Product Gene Name   

IRF8 peptide

[Similar Products]
 Product Synonym Gene Name    ICSBP1 [Similar Products]
 Antibody/Peptide Pairs    ICSBP1 / IRF8 peptide (MBS425759) is used for blocking the activity of ICSBP1/IRF8 antibody (MBS420502)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-QRSFFREN QQITV
 OMIM    601565
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 Species Reactivity    Human, Mouse, Rat, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of IRF8 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for IRF8. It may not necessarily be applicable to this product.
 NCBI GI #    4504567
 NCBI GeneID    3394
 NCBI Accession #    NP_002154.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002163.2 [Other Products]
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 UniProt Secondary Accession #    A0AV82 [Other Products]
 UniProt Related Accession #    Q02556 [Other Products]
 Molecular Weight    48,356 Da
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 NCBI Official Full Name    interferon regulatory factor 8
 NCBI Official Synonym Full Names    interferon regulatory factor 8
 NCBI Official Symbol    IRF8 [Similar Products]
 NCBI Official Synonym Symbols   
ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP
[Similar Products]
 NCBI Protein Information    interferon regulatory factor 8
 UniProt Protein Name    Interferon regulatory factor 8
 UniProt Synonym Protein Names   
Interferon consensus sequence-binding protein; H-ICSBP; ICSBP
 Protein Family    Interferon regulatory factor
 UniProt Gene Name    IRF8 [Similar Products]
 UniProt Synonym Gene Names    ICSBP1; IRF-8; H-ICSBP; ICSBP [Similar Products]
 UniProt Entry Name    IRF8_HUMAN
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 NCBI Summary for IRF8    Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IRF8    IRF8: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Interacts (via C-terminus) with TRIM21 (via C-terminus). Interacts with COPS2. By IFNG/IFN-gamma. Predominantly expressed in lymphoid tissues. Belongs to the IRF family.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: cytosol; nucleoplasm

Molecular Function: protein binding; RNA polymerase II transcription factor activity, enhancer binding

Biological Process: defense response to bacterium; defense response to protozoan; immune response; myeloid cell differentiation; negative regulation of transcription from RNA polymerase II promoter; phagocytosis; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; transcription, DNA-dependent

Disease: Immunodeficiency 32a; Monocyte And Dendritic Cell Deficiency, Autosomal Recessive
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 Research Articles on IRF8    1. cytarabine-induced upregulation of the IRF8 in leukemic cells involves increased levels of ZNF224, which can counteract the repressive activity of WT1 on the IRF8-promoter
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IRF8 peptidePathways associated with IRF8 peptide
 Reference Product  PubMed Publications
 IRF1 peptide  >36 publications with IRF8 and IRF1
 IRF2 peptide  >13 publications with IRF8 and IRF2
 TLR9 peptide  >10 publications with IRF8 and TLR9
 SPI1 peptide  >6 publications with IRF8 and SPI1
 STAT2 peptide  >4 publications with IRF8 and STAT2
 CIITA peptide  >3 publications with IRF8 and CIITA
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Pertussis Pathway antibodies  Pertussis Pathway Diagram
 Type II Interferon Signaling (IFNG) Pathway antibodies  Type II Interferon Signaling (IFNG) Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies  Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram
Diseases associated with IRF8 peptideOrgans/Tissues associated with IRF8 peptide
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >47 publications with IRF8 and Inflammation
 Nervous System Diseases Antibodies  >31 publications with IRF8 and Nervous System Diseases
 Disease Models, Animal Antibodies  >18 publications with IRF8 and Disease Models, Animal
 Multiple Sclerosis Antibodies  >18 publications with IRF8 and Multiple Sclerosis
 Necrosis Antibodies  >16 publications with IRF8 and Necrosis
 Cardiovascular Diseases Antibodies  >13 publications with IRF8 and Cardiovascular Diseases
 Lung Diseases Antibodies  >10 publications with IRF8 and Lung Diseases
 Brain Diseases Antibodies  >10 publications with IRF8 and Brain Diseases
 Kidney Diseases Antibodies  >8 publications with IRF8 and Kidney Diseases
 Arthritis, Rheumatoid Antibodies  >8 publications with IRF8 and Arthritis, Rheumatoid
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >118 publications with IRF8 and Blood
 Spleen Antibodies  >21 publications with IRF8 and Spleen
 Lymph Node Antibodies  >17 publications with IRF8 and Lymph Node
 Lung Antibodies  >15 publications with IRF8 and Lung
 Brain Antibodies  >14 publications with IRF8 and Brain
 Kidney Antibodies  >12 publications with IRF8 and Kidney
 Muscle Antibodies  >7 publications with IRF8 and Muscle
 Lymph Antibodies  >7 publications with IRF8 and Lymph
 Tonsil Antibodies  >4 publications with IRF8 and Tonsil
 Pharynx Antibodies  >4 publications with IRF8 and Pharynx
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