NP_000620.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,046 Da
NCBI Official Full Name
interferon alpha/beta receptor 1
NCBI Official Synonym Full Names
interferon alpha and beta receptor subunit 1
NCBI Official Synonym Symbols
AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC [Similar Products]
NCBI Protein Information
interferon alpha/beta receptor 1
UniProt Protein Name
Interferon alpha/beta receptor 1
UniProt Synonym Protein Names
Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1
UniProt Synonym Gene Names
UniProt Entry Name
INAR1_HUMAN
NCBI Summary for IFNAR1
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]
UniProt Comments for IFNAR1
IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells.
Protein type: Receptor, cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component: integral to plasma membrane; late endosome; lysosome; plasma membrane
Molecular Function: interferon-alpha/beta binding; interferon-alpha/beta receptor activity; protein binding
Biological Process: defense response to virus; interferon type I biosynthetic process; JAK-STAT cascade; positive regulation of interferon-beta production; positive regulation of interferon-gamma production; positive regulation of interleukin-1 beta secretion; positive regulation of transcription, DNA-dependent; regulation of peptidyl-tyrosine phosphorylation; response to lipopolysaccharide; response to virus; T cell activation
Research Articles on IFNAR1
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Products associated with IFNAR1 blocking peptide
Pathways associated with IFNAR1 blocking peptide
Diseases associated with IFNAR1 blocking peptide
Organs/Tissues associated with IFNAR1 blocking peptide
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