NP_001544.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,860 Da
NCBI Official Full Name
insulin-like growth factor-binding protein 7 isoform 1
NCBI Official Synonym Full Names
insulin like growth factor binding protein 7
NCBI Official Synonym Symbols
AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1 [Similar Products]
NCBI Protein Information
insulin-like growth factor-binding protein 7
UniProt Protein Name
Insulin-like growth factor-binding protein 7
UniProt Synonym Protein Names
IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor; TAF
UniProt Synonym Gene Names
UniProt Entry Name
IBP7_HUMAN
NCBI Summary for IGFBP7
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]
UniProt Comments for IGFBP7
IGFBP7: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS). RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.
Protein type: Cell cycle regulation; Secreted, signal peptide; Secreted; Cell adhesion
Chromosomal Location of Human Ortholog: 4q12
Cellular Component: extracellular matrix; extracellular region; extracellular space
Molecular Function: insulin-like growth factor binding; protein binding
Biological Process: cell adhesion; negative regulation of cell proliferation; regulation of cell growth
Disease: Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis
Research Articles on IGFBP7
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Products associated with IGFBP7 blocking peptide
Pathways associated with IGFBP7 blocking peptide
Diseases associated with IGFBP7 blocking peptide
Organs/Tissues associated with IGFBP7 blocking peptide
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