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IDE peptide :: Insulysin / Insulinase Peptide

Scan QR to view Datasheet Catalog #    MBS425175 IDE peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Insulysin / Insulinase (IDE), Peptide

★Popular Item★
 Also Known As   

Insulysin / Insulinase Immunizing Peptide

 Product Synonym Names    insulinase; insulysin; insulin-degrading enzyme; FLJ35968; INSULYSIN; Insulysin; Insulinase; Insulysin / Insulinase
 Product Gene Name   

IDE peptide

[Similar Products]
 Antibody/Peptide Pairs    Insulysin / Insulinase peptide (MBS425175) is used for blocking the activity of Insulysin/Insulinase antibody (MBS420078)
 Antibody/Peptide Pairs    Insulysin / Insulinase peptide (MBS425175) is used for blocking the activity of Insulysin/Insulinase antibody (MBS423722)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-QQYNFDRD NTE
 OMIM    146680
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 Species Reactivity    Human, Dog
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of IDE peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for IDE. It may not necessarily be applicable to this product.
 NCBI GI #    4826770
 NCBI GeneID    3416
 NCBI Accession #    NP_004960.1 [Other Products]
 NCBI Related Accession #    NP_001159418.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004969.1 [Other Products]
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 UniProt Secondary Accession #    Q5T5N2; B2R721; B7ZAU2; D3DR35 [Other Products]
 UniProt Related Accession #    P14735 [Other Products]
 Molecular Weight    54,240 Da
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 NCBI Official Full Name    insulysin
 NCBI Official Synonym Full Names    insulin degrading enzyme
 NCBI Official Symbol    IDE [Similar Products]
 NCBI Official Synonym Symbols   
INSULYSIN
[Similar Products]
 NCBI Protein Information    insulin-degrading enzyme
 UniProt Protein Name    Insulin-degrading enzyme
 UniProt Synonym Protein Names   
Abeta-degrading protease; Insulin protease; Insulinase; Insulysin
 Protein Family    IgM protease
 UniProt Gene Name    IDE [Similar Products]
 UniProt Synonym Gene Names    Insulinase [Similar Products]
 UniProt Entry Name    IDE_HUMAN
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 NCBI Summary for IDE    This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
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 UniProt Comments for IDE    IDE: Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. Belongs to the peptidase M16 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Cell surface; EC 3.4.24.56; Protease

Chromosomal Location of Human Ortholog: 10q23-q25

Cellular Component: cell surface; cytoplasm; cytosol; extracellular space; mitochondrion; nucleoplasm; nucleus; peroxisomal matrix; peroxisome; plasma membrane

Molecular Function: ATP binding; ATPase activity; beta-amyloid binding; beta-endorphin binding; glycoprotein binding; insulin binding; metalloendopeptidase activity; peptide binding; protein binding; protein homodimerization activity; receptor binding; ubiquitin binding; viral receptor activity; zinc ion binding

Biological Process: beta-amyloid metabolic process; determination of adult life span; entry of virus into host cell; hormone catabolic process; insulin receptor signaling pathway; negative regulation of proteolysis; positive regulation of protein oligomerization; protein heterooligomerization; protein homooligomerization; protein homotetramerization; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process
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 Research Articles on IDE    1. the mechanistic and molecular features of IDE-26S proteasome interaction in a cell experimental model, is reported.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IDE peptidePathways associated with IDE peptide
 Reference Product  PubMed Publications
 APP peptide  >66 publications with IDE and APP
 IAPP peptide  >15 publications with IDE and IAPP
 INS peptide  >12 publications with IDE and INS
 CCL3 peptide  >5 publications with IDE and CCL3
 CCL4 peptide  >5 publications with IDE and CCL4
 UBC peptide  >3 publications with IDE and UBC
 IGF2 peptide  >2 publications with IDE and IGF2
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
Diseases associated with IDE peptideOrgans/Tissues associated with IDE peptide
 Disease Name  Pubmed Publications
 Hepatitis Antibodies  >1083 publications with IDE and Hepatitis
 Liver Diseases Antibodies  >962 publications with IDE and Liver Diseases
 Carcinoma Antibodies  >645 publications with IDE and Carcinoma
 Cardiovascular Diseases Antibodies  >592 publications with IDE and Cardiovascular Diseases
 Immune System Diseases Antibodies  >356 publications with IDE and Immune System Diseases
 Carcinoma, Hepatocellular Antibodies  >318 publications with IDE and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >287 publications with IDE and Heart Diseases
 Liver Cirrhosis Antibodies  >281 publications with IDE and Liver Cirrhosis
 Adenocarcinoma Antibodies  >277 publications with IDE and Adenocarcinoma
 Liver Neoplasms Antibodies  >216 publications with IDE and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1449 publications with IDE and Blood
 Liver Antibodies  >1051 publications with IDE and Liver
 Brain Antibodies  >627 publications with IDE and Brain
 Muscle Antibodies  >388 publications with IDE and Muscle
 Vascular Antibodies  >385 publications with IDE and Vascular
 Bone Antibodies  >377 publications with IDE and Bone
 Heart Antibodies  >359 publications with IDE and Heart
 Lung Antibodies  >258 publications with IDE and Lung
 Kidney Antibodies  >212 publications with IDE and Kidney
 Skin Antibodies  >159 publications with IDE and Skin
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