NP_002154.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
interferon regulatory factor 8
NCBI Official Synonym Full Names
interferon regulatory factor 8
NCBI Protein Information
interferon regulatory factor 8; interferon consensus sequence binding protein 1
UniProt Protein Name
Interferon regulatory factor 8
UniProt Synonym Protein Names
Interferon consensus sequence-binding protein
UniProt Synonym Gene Names
UniProt Entry Name
IRF8_HUMAN
NCBI Summary for IRF8
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]
UniProt Comments for IRF8
Function: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes
By similarity.
Subunit structure: Interacts (via C-terminus) with TRIM21 (via C-terminus). Interacts with the BATF-JUNB heterodimer. Interacts with BATF (via bZIP domain); the interaction is direct
By similarity. Interacts with COPS2. Ref.4
Subcellular location: Nucleus.
Tissue specificity: Predominantly expressed in lymphoid tissues. Ref.1
Induction: By IFNG/IFN-gamma. Ref.1
Post-translational modification: Ubiquitinated. Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes
By similarity.
Sequence similarities: Belongs to the IRF family.Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
Research Articles on IRF8
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Products associated with IRF8 peptide
Pathways associated with IRF8 peptide
Diseases associated with IRF8 peptide
Organs/Tissues associated with IRF8 peptide
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