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JAM3 peptide :: JAMC Peptide

Scan QR to view Datasheet Catalog #    MBS425024 JAM3 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

JAMC (JAM3), Peptide

 Also Known As   

JAMC Immunizing Peptide

 Product Synonym Names    JAM3; junctional adhesion molecule 3; FLJ14529; JAM-C; JAMC; junctional adhesion molecule C
 Product Gene Name   

JAM3 peptide

[Similar Products]
 Product Synonym Gene Name    JAMC [Similar Products]
 Antibody/Peptide Pairs    JAMC peptide (MBS425024) is used for blocking the activity of JAMC antibody (MBS421843)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-KQDGESYK NPGKPD
 OMIM    606871
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 Species Reactivity    Human, Cow
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of JAM3 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for JAM3. It may not necessarily be applicable to this product.
 NCBI GI #    21361905
 NCBI GeneID    83700
 NCBI Accession #    NP_116190.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_032801.3 [Other Products]
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 UniProt Secondary Accession #    Q8WWL8; Q96FL1; B3KWG9 [Other Products]
 UniProt Related Accession #    Q9BX67 [Other Products]
 Molecular Weight    29,223 Da
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 NCBI Official Full Name    junctional adhesion molecule C
 NCBI Official Synonym Full Names    junctional adhesion molecule 3
 NCBI Official Symbol    JAM3 [Similar Products]
 NCBI Official Synonym Symbols   
JAMC; JAM-2; JAM-3; JAM-C
[Similar Products]
 NCBI Protein Information    junctional adhesion molecule C
 UniProt Protein Name    Junctional adhesion molecule C
 UniProt Synonym Protein Names   
JAM-2; Junctional adhesion molecule 3; JAM-3
 Protein Family    Junctional adhesion molecule
 UniProt Gene Name    JAM3 [Similar Products]
 UniProt Synonym Gene Names    JAM-C; JAM-3 [Similar Products]
 UniProt Entry Name    JAM3_HUMAN
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 NCBI Summary for JAM3    Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
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 UniProt Comments for JAM3    JAM3: Participates in cell-cell adhesion. It is a counter- receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis. Defects in JAM3 are the cause of hemorrhagic destruction of the brain with subependymal calcification and cataracts (HDBSCC). A syndrome characterized by congenital cataracts and severe brain abnormalities apparently resulting from hemorrhagic destruction of the brain tissue, including the cerebral white matter and basal ganglia. Patients manifest profound developmental delay, and other neurologic features included seizures, spasticity, and hyperreflexia. Brain imaging shows multifocal intraparenchymal hemorrhage with associated liquefaction and massive cystic degeneration, and calcification in the subependymal region and in brain tissue. Belongs to the immunoglobulin superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 11q25

Cellular Component: desmosome; extracellular space; Golgi apparatus; integral to membrane; plasma membrane; tight junction

Molecular Function: integrin binding; protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: adaptive immune response; angiogenesis; axon regeneration; cell-matrix adhesion; establishment of cell polarity; extracellular matrix organization and biogenesis; leukocyte migration; leukocyte migration during inflammatory response; myelination; myeloid progenitor cell differentiation; neutrophil homeostasis; spermatid development; transmission of nerve impulse

Disease: Hemorrhagic Destruction Of The Brain, Subependymal Calcification, And Cataracts
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 Research Articles on JAM3    1. Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with JAM3 peptideDiseases associated with JAM3 peptide
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >16 publications with JAM3 and Inflammation
 Disease Models, Animal Antibodies  >10 publications with JAM3 and Disease Models, Animal
 Uterine Cervical Neoplasms Antibodies  >5 publications with JAM3 and Uterine Cervical Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with JAM3 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >3 publications with JAM3 and Lung Neoplasms
 Heart Defects, Congenital Antibodies  >3 publications with JAM3 and Heart Defects, Congenital
 Necrosis Antibodies  >3 publications with JAM3 and Necrosis
 Fibrosis Antibodies  >2 publications with JAM3 and Fibrosis
 Adenocarcinoma Antibodies  >2 publications with JAM3 and Adenocarcinoma
 Hemorrhage Antibodies  >2 publications with JAM3 and Hemorrhage
Organs/Tissues associated with JAM3 peptide
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >50 publications with JAM3 and Blood
 Vascular Antibodies  >36 publications with JAM3 and Vascular
 Brain Antibodies  >12 publications with JAM3 and Brain
 Lung Antibodies  >11 publications with JAM3 and Lung
 Heart Antibodies  >8 publications with JAM3 and Heart
 Embryonic Tissue Antibodies  >6 publications with JAM3 and Embryonic Tissue
 Nerve Antibodies  >6 publications with JAM3 and Nerve
 Skin Antibodies  >6 publications with JAM3 and Skin
 Bone Antibodies  >5 publications with JAM3 and Bone
 Kidney Antibodies  >5 publications with JAM3 and Kidney
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