NP_055948.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,052 Da
NCBI Official Full Name
C-Jun-amino-terminal kinase-interacting protein 3 isoform 1
NCBI Official Synonym Full Names
mitogen-activated protein kinase 8 interacting protein 3
NCBI Protein Information
C-Jun-amino-terminal kinase-interacting protein 3
UniProt Protein Name
C-Jun-amino-terminal kinase-interacting protein 3
UniProt Synonym Protein Names
JNK MAP kinase scaffold protein 3; Mitogen-activated protein kinase 8-interacting protein 3
UniProt Synonym Gene Names
UniProt Entry Name
JIP3_HUMAN
NCBI Summary for MAPK8IP3
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for MAPK8IP3
JIP3: a member of the JNK-interacting protein group of scaffold proteins that selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies in the mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: axolemma; cytoplasm; dendrite; Golgi membrane; smooth endoplasmic reticulum
Molecular Function: JUN kinase binding; kinesin binding; MAP-kinase scaffold activity; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding; receptor signaling complex scaffold activity
Biological Process: activation of JNK activity; alveolus development; axon guidance; forebrain development; in utero embryonic development; post-embryonic development; protein localization; regulation of gene expression; regulation of JNK cascade; respiratory gaseous exchange; vesicle-mediated transport
Research Articles on MAPK8IP3
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Products associated with MAPK8IP3 blocking peptide
Pathways associated with MAPK8IP3 blocking peptide
Diseases associated with MAPK8IP3 blocking peptide
Organs/Tissues associated with MAPK8IP3 blocking peptide
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