NP_005753.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
79,474 Da
NCBI Official Full Name
transcription intermediary factor 1-beta
NCBI Official Synonym Full Names
tripartite motif containing 28
NCBI Official Synonym Symbols
KAP1; TF1B; RNF96; TIF1B; PPP1R157 [Similar Products]
NCBI Protein Information
transcription intermediary factor 1-beta
UniProt Protein Name
Transcription intermediary factor 1-beta
UniProt Synonym Protein Names
E3 SUMO-protein ligase TRIM28 (EC:6.3.2.-); KRAB-associated protein 1; KAP-1; KRAB-interacting protein 1; KRIP-1; Nuclear corepressor KAP-1; RING finger protein 96; Tripartite motif-containing protein 28
UniProt Synonym Gene Names
UniProt Entry Name
TIF1B_HUMAN
NCBI Summary for TRIM28
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]
UniProt Comments for TRIM28
TIF1B: an atypical protein kinase that functions as a transcriptional coactivator. Mediates transcriptional regulation by interaction with the Kruppel-associated box (KRAB) repression domain found in many transcription factors. Binds to the negative regulatory domain of c-Myb and negatively regulates the c-Myb-dependent trans-activation. Localizes to the nucleus and is thought to associate with specific chromatin regions. Phosphorylated in an ATM-dependent manner following double-strand breaks. Its phosphorylation in response to DNA damage leads to chromatin relaxation. A member of the tripartite motif family. The tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
Protein type: Ubiquitin ligase; EC 6.3.2.-; Kinase, protein; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Protein kinase, atypical; Ubiquitin conjugating system; Ligase; ATYPICAL group; TIF1 family
Chromosomal Location of Human Ortholog: 19q13.4
Cellular Component: nuclear heterochromatin; nucleoplasm; nucleus
Molecular Function: DNA binding; ligase activity; protein binding; protein kinase activity; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; zinc ion binding
Biological Process: chromatin modification; convergent extension involved in axis elongation; DNA methylation during embryonic development; DNA repair; embryo implantation; epithelial to mesenchymal transition; innate immune response; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of DNA repair; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; protein oligomerization; protein sumoylation; protein ubiquitination; Ras protein signal transduction; transcription initiation from RNA polymerase II promoter
Research Articles on TRIM28
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Organs/Tissues associated with TRIM28 blocking peptide
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