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SLC12A7 peptide :: KCC4 / SLC12A7 Peptide

Scan QR to view Datasheet Catalog #    MBS425174 SLC12A7 peptide
Unit / Price
0.1 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KCC4 / SLC12A7, Peptide

 Also Known As   

KCC4 / SLC12A7 Immunizing Peptide

 Product Synonym Names    SLC12A7; solute carrier family 12 (potassium/chloride transporters), member 7; DKFZP434F076; KCC4; potassium/chloride transporter KCC4; KCC4 / SLC12A7
 Product Gene Name   

SLC12A7 peptide

[Similar Products]
 Product Synonym Gene Name    KCC4 [Similar Products]
 Antibody/Peptide Pairs    KCC4 / SLC12A7 peptide (MBS425174) is used for blocking the activity of KCC4/SLC12A7 antibody (MBS420915)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    C-QLIHDRNT ASHT
 OMIM    604879
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 Species Reactivity    Human, Mouse
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 Form/Format    100ug of dried peptide
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 Preparation and Storage    Shipped at ambient temperature, store at -20 degree C
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of SLC12A7 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for SLC12A7. It may not necessarily be applicable to this product.
 NCBI GI #    123701900
 NCBI GeneID    10723
 NCBI Accession #    NP_006589.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006598.2 [Other Products]
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 UniProt Secondary Accession #    Q4G0F3; Q96I81; Q9H7I3; Q9H7I7; Q9UFW2; A6NDS8 [Other Products]
 UniProt Related Accession #    Q9Y666 [Other Products]
 Molecular Weight    28,258 Da
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 NCBI Official Full Name    solute carrier family 12 member 7
 NCBI Official Synonym Full Names    solute carrier family 12 member 7
 NCBI Official Symbol    SLC12A7 [Similar Products]
 NCBI Official Synonym Symbols   
KCC4
[Similar Products]
 NCBI Protein Information    solute carrier family 12 member 7
 UniProt Protein Name    Solute carrier family 12 member 7
 UniProt Synonym Protein Names   
Electroneutral potassium-chloride cotransporter 4; K-Cl cotransporter 4
 Protein Family    Solute carrier family
 UniProt Gene Name    SLC12A7 [Similar Products]
 UniProt Synonym Gene Names    KCC4 [Similar Products]
 UniProt Entry Name    S12A7_HUMAN
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 UniProt Comments for SLC12A7    KCC4: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification. Belongs to the SLC12A transporter family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 5p15

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: potassium ion symporter activity; potassium:chloride symporter activity; protein kinase binding

Biological Process: cell volume homeostasis; ion transport; synaptic transmission; transport
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 Research Articles on SLC12A7    1. The Wnk3 protein isoforms have a similar effect on SLC12 cotransporters. NKCC1/2 and NCC were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SLC12A7 peptideDiseases associated with SLC12A7 peptide
 Products by Pathway  Pathway Diagram
 Cation-coupled Chloride Cotransporters Pathway antibodies  Cation-coupled Chloride Cotransporters Pathway Diagram
 Collecting Duct Acid Secretion Pathway antibodies  Collecting Duct Acid Secretion Pathway Diagram
 Collecting Duct Acid Secretion Pathway antibodies  Collecting Duct Acid Secretion Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram
 Disease Name  Pubmed Publications
 Uterine Cervical Neoplasms Antibodies  >2 publications with SLC12A7 and Uterine Cervical Neoplasms
 Ovarian Neoplasms Antibodies  >2 publications with SLC12A7 and Ovarian Neoplasms
 Anemia, Hemolytic Antibodies  >2 publications with SLC12A7 and Anemia, Hemolytic
 Anemia Antibodies  >2 publications with SLC12A7 and Anemia
 Kidney Diseases Antibodies  >2 publications with SLC12A7 and Kidney Diseases
 Carcinoma Antibodies  >1 publications with SLC12A7 and Carcinoma
 Hypertension Antibodies  >1 publications with SLC12A7 and Hypertension
 Hyperplasia Antibodies  >1 publications with SLC12A7 and Hyperplasia
 Necrosis Antibodies  >1 publications with SLC12A7 and Necrosis
Organs/Tissues associated with SLC12A7 peptide
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with SLC12A7 and Brain
 Kidney Antibodies  >11 publications with SLC12A7 and Kidney
 Muscle Antibodies  >4 publications with SLC12A7 and Muscle
 Stomach Antibodies  >4 publications with SLC12A7 and Stomach
 Lung Antibodies  >3 publications with SLC12A7 and Lung
 Heart Antibodies  >2 publications with SLC12A7 and Heart
 Nerve Antibodies  >2 publications with SLC12A7 and Nerve
 Liver Antibodies  >1 publications with SLC12A7 and Liver
 Testis Antibodies  >1 publications with SLC12A7 and Testis
 Pancreas Antibodies  >1 publications with SLC12A7 and Pancreas
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