AAI10574.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
KCNB1 protein
NCBI Official Synonym Full Names
potassium voltage-gated channel, Shab-related subfamily, member 1
NCBI Protein Information
potassium voltage-gated channel subfamily B member 1; h-DRK1 K(+) channel; potassium channel protein DRK1; delayed rectifier potassium channel 1; delayed rectifier potassium channel Kv2.1; voltage-gated potassium channel subunit Kv2.1
UniProt Protein Name
Potassium voltage-gated channel subfamily B member 1
UniProt Synonym Protein Names
Delayed rectifier potassium channel 1; DRK1; h-DRK1; Voltage-gated potassium channel subunit Kv2.1
UniProt Synonym Gene Names
UniProt Entry Name
KCNB1_HUMAN
NCBI Summary for KCNB1
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNB1
Kv2.1: a potassium voltage-gated channel protein of subfamily B. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting K ions pass in accordance with their electrochemical gradient.
Protein type: Channel, cation; Membrane protein, integral; Channel, potassium; Channel, ligand-gated; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 20q13.2
Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; dendrite; integral to membrane; plasma membrane
Molecular Function: protein binding; outward rectifier potassium channel activity; delayed rectifier potassium channel activity; protein N-terminus binding
Biological Process: synaptic transmission; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerization
Disease: Epileptic Encephalopathy, Early Infantile, 26
Research Articles on KCNB1
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Products associated with KCNB1 peptide
Pathways associated with KCNB1 peptide
Diseases associated with KCNB1 peptide
Organs/Tissues associated with KCNB1 peptide
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