NP_004510.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
93,599 Da
NCBI Official Full Name
potassium voltage-gated channel subfamily KQT member 3 isoform 1
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily Q member 3
NCBI Protein Information
potassium voltage-gated channel subfamily KQT member 3
UniProt Protein Name
Potassium voltage-gated channel subfamily KQT member 3
UniProt Synonym Protein Names
KQT-like 3; Potassium channel subunit alpha KvLQT3; Voltage-gated potassium channel subunit Kv7.3
UniProt Entry Name
KCNQ3_HUMAN
NCBI Summary for KCNQ3
This gene encodes a protein that functions in the regulation of neuronal excitability. The encoded protein forms an M-channel by associating with the products of the related KCNQ2 or KCNQ5 genes, which both encode integral membrane proteins. M-channel currents are inhibited by M1 muscarinic acetylcholine receptors and are activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Comments for KCNQ3
Kv7.3: Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Defects in KCNQ3 are the cause of benign familial neonatal seizures type 2 (BFNS2). A disorder characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium
Chromosomal Location of Human Ortholog: 8q24
Cellular Component: cell surface; plasma membrane; voltage-gated potassium channel complex
Molecular Function: calmodulin binding; delayed rectifier potassium channel activity; potassium channel activity; voltage-gated potassium channel activity
Biological Process: membrane hyperpolarization; potassium ion transport; synaptic transmission
Disease: Seizures, Benign Familial Neonatal, 2
Research Articles on KCNQ3
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Products associated with KCNQ3 blocking peptide
Pathways associated with KCNQ3 blocking peptide
Diseases associated with KCNQ3 blocking peptide
Organs/Tissues associated with KCNQ3 blocking peptide
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