NP_062816.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
102,365 Da
NCBI Official Full Name
potassium voltage-gated channel subfamily KQT member 5 isoform 1
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily Q member 5
NCBI Official Synonym Symbols
NCBI Protein Information
potassium voltage-gated channel subfamily KQT member 5
UniProt Protein Name
Potassium voltage-gated channel subfamily KQT member 5
UniProt Synonym Protein Names
KQT-like 5; Potassium channel subunit alpha KvLQT5; Voltage-gated potassium channel subunit Kv7.5
UniProt Entry Name
KCNQ5_HUMAN
NCBI Summary for KCNQ5
This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
UniProt Comments for KCNQ5
Kv7.5: Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6q14
Cellular Component: clathrin coat; plasma membrane; voltage-gated potassium channel complex
Molecular Function: delayed rectifier potassium channel activity; inward rectifier potassium channel activity; protein binding; voltage-gated potassium channel activity
Biological Process: protein complex assembly; synaptic transmission
Research Articles on KCNQ5
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Pathways associated with KCNQ5 blocking peptide
Diseases associated with KCNQ5 blocking peptide
Organs/Tissues associated with KCNQ5 blocking peptide
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